Department of Pharmaceutics and Pharmacology, Faculty of Pharmacy, 7th of April University, Al-Zawia, Libya.
Nat Prod Res. 2012;26(16):1504-9. doi: 10.1080/14786419.2011.563421. Epub 2011 Oct 18.
The aim of this study is to investigate the antitumour and antioxidant activities of the ethanol extract of Scutia myrtina (EESM) against Ehrlich's ascites carcinoma (EAC) in mice. Twenty-four hours after tumour inoculation, EESM was administered at doses 100, 200 and 300 mg kg⁻¹ bodyweight/mice/day for 21 days. EESM caused a significant (p < 0.01) decrease in ascites volume, packed cell volume and viable cell count, and also prolonged the life span of EAC tumour-bearing mice. Haematological profiles reverted to near-normal levels in extract-treated mice (p < 0.01). EESM also produced protective effects by significantly decreasing the activity of serum enzymes and bilirubin and increasing the protein and uric acid levels (p < 0.05). EESM significantly (p < 0.05) decreased the levels of lipid peroxidation, while it significantly (p < 0.05) increased the levels of enzymatic and non-enzymatic antioxidants. The results indicate that EESM exhibited significant antitumour and antioxidant activities in EAC-bearing mice.
本研究旨在探讨对叶榕（Scutia myrtina）乙醇提取物（EESM）对艾氏腹水癌（EAC）小鼠的抗肿瘤和抗氧化活性。肿瘤接种后 24 小时，以 100、200 和 300 mg/kg 体重/小鼠/天的剂量给予 EESM，连续给药 21 天。EESM 可显著（p<0.01）降低腹水体积、红细胞压积和活细胞计数，并延长 EAC 荷瘤小鼠的寿命。在提取物治疗的小鼠中，血液学特征恢复到接近正常水平（p<0.01）。EESM 还通过显著降低血清酶和胆红素的活性以及增加蛋白质和尿酸水平（p<0.05）产生保护作用。EESM 可显著（p<0.05）降低脂质过氧化水平，同时可显著（p<0.05）增加酶和非酶抗氧化剂的水平。结果表明，EESM 对 EAC 荷瘤小鼠表现出显著的抗肿瘤和抗氧化活性。
