从黄花棘豆中提取的一种新木脂素。

A new lignan from Oxytropis myriophylla.

机构信息

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, PR China.

出版信息

Nat Prod Res. 2012;26(14):1285-90. doi: 10.1080/14786419.2011.566871. Epub 2011 Oct 19.

DOI:10.1080/14786419.2011.566871

PMID:22007757

Abstract

The 70% alcohol extract of Oxytropis myriophylla (PALL.) DC. (Leguminosae) exhibited high radical scavenging activity (IC(50) value: 88.0 µg mL(-1) and 86.7 µg mL(-1)) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. Further chemical investigation led the isolation of one new lignan, namely myriophylloside G (1), together with three known compounds. Their structural elucidations of all the compounds were based on extensive spectroscopic methods, including HRESIMS and 2D NMR experiments (HSQC, HMBC and (1)H-(1)HCOSY) and by comparison with reference values.

摘要

黄花棘豆（PALL.）（豆科）70%的醇提取物表现出很高的自由基清除活性（IC50 值：88.0μg·mL-1 和 86.7μg·mL-1），在 1,1-二苯基-2-苦基肼（DPPH）和 2,2'-联氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除测定中。进一步的化学研究导致分离出一种新的木脂素，即三叶豆苷 G（1），以及三种已知化合物。所有化合物的结构鉴定均基于广泛的光谱方法，包括高分辨质谱和二维 NMR 实验（HSQC、HMBC 和 1H-1HCOSY），并与参考值进行比较。