Chugh S N, Singhal H R, Mehta L, Chugh K, Shankar V, Malhotra K C
Radioisotope Section, Medical College and Hospital, Rohtak.
J Assoc Physicians India. 1990 Jun;38(6):398-9.
Plasma renin activity (PRA) was estimated in 30 patients with aluminium phosphide (AIP) poisoning (study group) admitted in shock. Ten patients in shock other than due to AIP poisoning (Group II A) and 20 normal healthy subjects (Group II B) served as controls. The PRA was significantly higher in the study group and group II A as compared to normal healthy subjects (p less than 0.001). Significantly higher PRA was found in the study group as compared to Group II A (p less than 0.001). The initial higher PRA continued to rise further in the study group but it started decreasing in Group II A as the duration of shock advanced. Continuation of shock in AIP poisoning was probably due to slow release of toxic PH3 gas, which was detected by positive silver nitrate paper test. The rise in PRA was directly proportional to the dose of pesticide consumed. There was direct relationship of mortality with increased PRA. Angiotensin converting enzyme inhibitors may have a role in combating shock in AIp poisoning.
对30例磷化铝（AIP）中毒且处于休克状态的患者（研究组）测定了血浆肾素活性（PRA）。10例非AIP中毒所致休克的患者（II A组）和20名正常健康受试者（II B组）作为对照。与正常健康受试者相比，研究组和II A组的PRA显著更高（p<0.001）。与II A组相比，研究组的PRA显著更高（p<0.001）。研究组最初较高的PRA继续进一步升高，但随着休克持续时间延长，II A组的PRA开始下降。AIP中毒时休克持续存在可能是由于有毒的PH3气体缓慢释放，硝酸银试纸检测呈阳性可证实这一点。PRA升高与摄入的农药剂量成正比。死亡率与PRA升高直接相关。血管紧张素转换酶抑制剂可能在对抗AIP中毒性休克中发挥作用。
