Chugh S N, Kumar P, Aggarwal H K, Sharma A, Mahajan S K, Malhotra K C
Department of Medicine, Medical College and Hospital, Haryana.
J Assoc Physicians India. 1994 May;42(5):373-5.
The results of an open randomised study on the efficacy of magnesium sulphate therapy in aluminium phosphide poisoning are presented. One hundred and fifty five patients divided in three groups and matched for age, sex, dose, duration and severity of poisoning constituted the subject matter. Significant hypomagnesemia was observed in patients who did not receive magnesium sulphate (group 1). Two dose schedules of MgSO4 therapy were tried. The dose schedule No.1 given to patients of group 2 did not raise the magnesium levels significantly as compared to controls (group 4). The difference in the mortality between groups 1 & 2 was also not significant. On the other hand, the dose schedule No.2 given to patients of group 3 raised the magnesium levels significantly and these remained above normal limits throughout the observed period. This dose schedule brought down the mortality significantly than dose schedule No.1 (p < 0.001). It was also found that dose schedule No.2 has been effective in reducing the mortality irrespective of dose of pesticide consumed and its efficacy was due to rapid rise in magnesium levels. It is suggested that hypomagnesemia might be responsible for high mortality of patients of aluminium phosphide poisoning and its correction has beneficial effect on the management and ultimate favourable outcome of the illness.
本文介绍了一项关于硫酸镁治疗磷化铝中毒疗效的开放性随机研究结果。155名患者被分为三组，根据年龄、性别、中毒剂量、持续时间和严重程度进行匹配，构成研究对象。未接受硫酸镁治疗的患者（第1组）出现了显著的低镁血症。尝试了两种硫酸镁治疗剂量方案。与对照组（第4组）相比，给予第2组患者的第1种剂量方案并未显著提高镁水平。第1组和第2组之间的死亡率差异也不显著。另一方面，给予第3组患者的第2种剂量方案显著提高了镁水平，并且在整个观察期内这些水平一直高于正常范围。该剂量方案的死亡率显著低于第1种剂量方案（p < 0.001）。还发现，无论摄入的农药剂量如何，第2种剂量方案在降低死亡率方面均有效，其疗效归因于镁水平的快速升高。提示低镁血症可能是磷化铝中毒患者高死亡率的原因，纠正低镁血症对疾病的治疗和最终良好结局具有有益作用。
