Key Laboratory for Phytochemistry of Shaanxi Province, Department of Chemistry & Chemical Engineering, Baoji University of Arts and Science, Baoji, Shaanxi 721013, P.R. China.
Nat Prod Res. 2012;26(22):2099-102. doi: 10.1080/14786419.2011.616505. Epub 2011 Oct 18.
In order to obtain the active compounds against third armyworm (Mythimna separata) contained in Aconitum sinomontanum Nakai by solvent partition, successive fractionation on silica gel and bioassay by the conventional leaf disc method, three diterpenoidal alkaloids were isolated for the first time from the roots of A. sinomontanum Nakai. Their structures were established as demethylenedelcorine, 18-O-methylgigactonine and lepenine based on their spectral data and X-ray diffraction analysis. Demethylenedelcorine and 18-O-methylgigactonine exhibited better pesticidal activities against M. separata, while lepenine had the induce-feeding activity against M. separata. The three diterpenoidal alkaloids exhibited bactericidal and fungicidal activities against certain kinds of the tested bacteria and fungi.
为了从唐松草中获得具有活性的化合物来防治第三粘虫（Mythimna separata），通过溶剂萃取、硅胶连续分馏和常规叶盘法生物测定，从唐松草的根部首次分离出三种二萜生物碱。基于它们的光谱数据和 X 射线衍射分析，确定了它们的结构分别为去甲二氢碎叶碱、18-O-甲基盖康定和莱皮宁。去甲二氢碎叶碱和 18-O-甲基盖康定对第三粘虫表现出更好的杀虫活性，而莱皮宁对第三粘虫具有诱食活性。三种二萜生物碱对某些测试的细菌和真菌具有杀菌和抑菌活性。
