Department of Pediatrics, The University of Tokyo Hospital, Japan.
Epidemiol Infect. 2012 Aug;140(8):1497-502. doi: 10.1017/S0950268811002044. Epub 2011 Oct 5.
We examined pertussis hospitalizations among infants aged <1 year between 2006 and 2008 using the nationwide inpatient database in Japan. A total of 660 infants hospitalized for pertussis were identified. Peak incidence occurred at age 1 month and infants aged 0-2 months (too young for pertussis vaccination) and ≥3 months (eligible for at least one dose of vaccination) accounted for 44·5% and 55·5% of hospitalizations, respectively. Complications related to pertussis were found in 165 (25·0%) cases, including one death; the age at admission did not differ significantly between patients with and those without complications (mean age 4·1 vs. 4·5 months, P=0·12). Seventeen patients required mechanical ventilation. Of the 17 cases, 14 infants were aged <3 months and three infants were aged ≥3 months. Our findings highlight that the vaccination schedule against pertussis may often be delayed in Japan.
我们使用日本全国住院患者数据库，调查了 2006 年至 2008 年期间年龄<1 岁的婴儿百日咳住院情况。共确定了 660 名因百日咳住院的婴儿。发病高峰出现在 1 月龄，0-2 月龄（太小而不能进行百日咳疫苗接种）和≥3 月龄（至少接种一剂疫苗合格）的婴儿分别占住院病例的 44.5%和 55.5%。在 165 例（25.0%）与百日咳相关的并发症中发现了一例死亡；有并发症和无并发症患者的入院年龄无显著差异（平均年龄分别为 4.1 个月和 4.5 个月，P=0.12）。17 例患者需要机械通气。在这 17 例中，14 例婴儿<3 个月，3 例婴儿≥3 个月。我们的研究结果表明，日本的百日咳疫苗接种计划可能经常被延迟。
