Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Cancer Causes Control. 2012 Jan;23(1):59-67. doi: 10.1007/s10552-011-9856-y. Epub 2011 Oct 19.
Data from epidemiological studies related to the association of cholecystectomy and pancreatic cancer (PaC) risk are inconsistent. We conducted a meta-analysis of observational studies to explore this relationship.
We identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 30 June 2011, and by searching the reference lists of pertinent articles. Summary relative risks with their 95% confidence intervals were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I (2).
A total of 18 studies (10 case-control studies, eight cohort studies) were included in this meta-analysis. Analysis of these 18 studies found that cholecystectomy was associated with a 23% excess risk of PaC (SRR = 1.23, 95% CI = 1.12-1.35), with moderate heterogeneity among these studies (p (heterogeneity) = 0.006, I (2) = 51.0%). Sub-grouped analyses revealed that the increased risk of PaC was independent of geographic location, gender, study design and confounders. There was no publication bias in the current meta-analysis.
The results of this meta-analysis suggest that individuals with a history of cholecystectomy may have an increased risk of pancreatic cancer.
有关胆囊切除术与胰腺癌（PaC）风险关联的流行病学研究数据不一致。我们进行了一项观察性研究的荟萃分析，以探讨这种关系。
我们通过对 Medline（从 1966 年 1 月 1 日开始）和 EMBASE（从 1974 年 1 月 1 日开始）的文献检索，以及截至 2011 年 6 月 30 日的相关文章的参考文献进行搜索，确定了研究。使用随机效应模型计算汇总相对风险及其 95%置信区间。使用 Cochran's Q 统计量和 I（2）评估研究间的异质性。
这项荟萃分析共纳入了 18 项研究（10 项病例对照研究，8 项队列研究）。对这 18 项研究的分析发现，胆囊切除术与 PaC 的 23%超额风险相关（SRR = 1.23，95%CI = 1.12-1.35），这些研究之间存在中度异质性（p（异质性）= 0.006，I（2）= 51.0%）。亚组分析表明，PaC 的风险增加与地理位置、性别、研究设计和混杂因素无关。本荟萃分析无发表偏倚。
这项荟萃分析的结果表明，有胆囊切除术史的个体可能患胰腺癌的风险增加。
