Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Horm Metab Res. 2011 Oct;43(11):809-15. doi: 10.1055/s-0031-1287767. Epub 2011 Oct 18.
Visceral fat accumulation relates to cardiovascular risk factors, but the underlying mechanisms are not well understood. We investigated the role of visceral adipocyte triglyceride breakdown (lipolysis) for several risk factors of cardiovascular disease. In 73 obese women, fat mass and distribution, blood pressure, blood samples for cardiometabolic risk factors, and whole-body insulin sensitivity were determined. A subcutaneous and a visceral fat biopsy were taken. Fat cell glycerol release after stimulation with a major lipolytic hormone, noradrenaline, was measured. In simple regression analysis, visceral fat cell lipolysis, but not subcutaneous adipocyte lipolysis was related to components of the metabolic syndrome. Moreover, subjects in the highest quartile of catecholamine-induced visceral lipolysis had higher levels of systolic blood pressure, estimated liver fat, plasma levels of glucose, insulin, cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B and lower whole-body insulin sensitivity than those in the lowest quartile (p=0.0004-0.048). Among subjects with the metabolic syndrome, visceral fat cell lipolysis was 40% higher than in the remaining subjects (p=0.0052). Catecholamine-activated lipolysis in visceral but not subcutaneous fat cells is associated with cardiovascular risk factors in obesity.
内脏脂肪堆积与心血管危险因素有关，但其中的潜在机制尚不清楚。我们研究了内脏脂肪细胞甘油三酯分解（脂肪分解）在几种心血管疾病危险因素中的作用。在 73 名肥胖女性中，测定了体脂肪量和分布、血压、心血管代谢危险因素的血液样本以及全身胰岛素敏感性。同时进行了皮下和内脏脂肪活检。用主要的脂肪分解激素去甲肾上腺素刺激后，测量脂肪细胞甘油的释放量。在简单回归分析中，内脏脂肪细胞脂肪分解，而不是皮下脂肪细胞脂肪分解与代谢综合征的成分有关。此外，儿茶酚胺诱导的内脏脂肪分解最高四分位数的受试者收缩压、估计的肝脂肪、血糖、胰岛素、胆固醇、LDL-胆固醇、甘油三酯和载脂蛋白 B 的血浆水平以及全身胰岛素敏感性均高于最低四分位数（p=0.0004-0.048）。在患有代谢综合征的受试者中，内脏脂肪细胞脂肪分解比其余受试者高 40%（p=0.0052）。儿茶酚胺激活的内脏脂肪细胞而非皮下脂肪细胞的脂肪分解与肥胖症中的心血管危险因素有关。
