Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Eur J Nucl Med Mol Imaging. 2012 Feb;39(2):220-5. doi: 10.1007/s00259-011-1965-z. Epub 2011 Oct 19.
In studies where [(11)C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches.
Eleven male smokers were scanned twice with RAC on separate days while wearing TNP.
Across the striatum, test-retest variability was 7.63 ± 5.88; percent change in binding potential was 1.11 ± 9.83; and the intraclass correlation coefficient was 0.91 (p < 0.0001).
Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine.
在使用 [(11)C]raclopride（RAC）正电子发射断层扫描（PET）来评估纹状体多巴胺变化的研究中，控制可能改变多巴胺水平的认知状态（如药物渴求）非常重要。在吸烟人群中，经皮尼古丁贴片（TNP）可以控制尼古丁的渴望，但尼古丁贴片对 RAC 结合的影响尚不清楚。因此，我们试图确定在使用尼古丁贴片的情况下 RAC 结合的测试-重测可靠性。
11 名男性吸烟者在两天内分别佩戴 TNP 进行两次 RAC 扫描。
整个纹状体，测试-重测的可变性为 7.63 ± 5.88；结合潜力的百分比变化为 1.11 ± 9.83；组内相关系数为 0.91（p < 0.0001）。
在佩戴尼古丁贴片的吸烟者中，RAC 结合的基线具有高度的可重复性。这表明 TNP 是一种可接受的方法，可用于控制使用 RAC 检查多巴胺变化的研究中的吸烟渴望。
