Department of Anatomy, Gulf Medical College, PO Box 4184, Ajman, United Arab Emirates.
Singapore Med J. 2011 Oct;52(10):742-6.
Testicular torsion is a medical emergency, especially in male neonates and adolescents. It is a common clinical outcome and a significant urological issue. From the literature, it is evident that the use of antioxidants in the prevention of testicular reperfusion injury following detorsion is conflicting. This study was conducted to investigate the role of vitamin E in testicular reperfusion injury following detorsion.
Male Wistar albino rats were divided into Groups I, II, III and IV. Only Group IV rats were pre-treated with vitamin E 100 mg/kg body weight for 30 days. Ischaemia was induced manually by rotating the rat testis to 720 degrees clockwise and counter rotating for reperfusion. The testes were fixed in Bouin's fluid and processed for histopathological examination.
A significant decrease in the standard tubular diameter and epithelial height was observed in Group III rats compared to those in Groups I and II. However, the seminiferous tubules in Group IV rats showed recovery in the standard tubular diameter and epithelial height when compared with the untreated control groups.
The results showed that vitamin E, when administered before torsion of the spermatic cord in rats, provided significant protection against acute testicular torsion and detorsion injury.
睾丸扭转是一种医学急症，尤其在男婴和青少年中更为常见。它是一种常见的临床后果，也是一个重要的泌尿科问题。从文献中可以明显看出，在扭转复位后预防睾丸再灌注损伤中使用抗氧化剂的效果存在争议。本研究旨在探讨维生素 E 在扭转复位后睾丸再灌注损伤中的作用。
雄性 Wistar 白化大鼠分为 I、II、III 和 IV 组。只有 IV 组大鼠预先用 100mg/kg 体重的维生素 E 处理 30 天。通过顺时针旋转大鼠睾丸 720 度并反方向旋转来诱导缺血，然后进行再灌注。将睾丸固定在 Bouin 液中，并进行组织病理学检查。
与 I 组和 II 组相比，III 组大鼠的标准管状直径和上皮高度显著降低。然而，与未处理的对照组相比，IV 组大鼠的精曲小管在标准管状直径和上皮高度方面显示出恢复。
结果表明，在大鼠精索扭转之前给予维生素 E，可以对急性睾丸扭转和复位损伤提供显著的保护作用。
