生物衍生的聚电解质纳米凝胶用于稳健的抗原负载和疫苗佐剂效应。

Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects.

机构信息

Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea.

出版信息

Small. 2011 Dec 2;7(23):3281-6. doi: 10.1002/smll.201101836. Epub 2011 Oct 19.

DOI:10.1002/smll.201101836

PMID:22009658

Abstract

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

摘要

本文提出了一种简便而稳健的策略，用于合成生物衍生的聚电解质纳米凝胶，用于蛋白质抗原负载和疫苗佐剂系统，可改善体液（Th2）和细胞免疫（Th1）。合成的聚电解质纳米凝胶促进抗原被抗原呈递细胞摄取，并强烈诱导卵清蛋白特异性 INF-γ产生细胞、细胞毒性 T 细胞活性和抗体产生。