利用肟键联策略的超分子脲嘧啶嘧啶酮-肽缀合物的模块化合成。
Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy.
机构信息
Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology (TU/e), PO Box 513, 5600 MB, Eindhoven, The Netherlands.
出版信息
Chem Commun (Camb). 2012 Feb 1;48(10):1452-4. doi: 10.1039/c1cc14728e. Epub 2011 Oct 18.
PMID:22010132
Abstract
A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.
摘要
一种方便的方法是以模块化的方式在简便和可扩展的方式制备超分子生物缀合物，其中自组装单元和肽通过肟化学偶联。我们在此报告了生物活性脲嘧啶嘧啶基肽缀合物的合成及其在纤维结构中的自组装。
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