利用DNA链置换实现多组分超分子聚合物体系中纳米级元素的可逆负载
Reversible Loading of Nanoscale Elements on a Multicomponent Supramolecular Polymer System by Using DNA Strand Displacement.
作者信息
Noteborn Willem E M, Saez Talens Victorio, Kieltyka Roxanne E
机构信息
Department of Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA, Leiden, The Netherlands.
出版信息
Chembiochem. 2017 Oct 18;18(20):1995-1999. doi: 10.1002/cbic.201700441. Epub 2017 Sep 7.
Nucleic acids are excellent building blocks to enable switchable character in supramolecular polymer materials because of their inherent dynamic character and potential for orthogonal self-assembly. Herein, DNA-grafted squaramide bola-amphiphiles are used in a multicomponent supramolecular polymer system and it is shown that they can be addressed by DNAlabeled gold nanoparticles (5 and 15 nm) through sequence complementarity. These nanoparticles can be selectively erased or rewritten on-demand by means of DNA-strand displacement.
由于其固有的动态特性和正交自组装的潜力，核酸是使超分子聚合物材料具有可切换特性的优良构建单元。在此，DNA接枝的方酸二酰胺双性分子被用于多组分超分子聚合物体系中，结果表明，它们可以通过序列互补性被DNA标记的金纳米颗粒（5纳米和15纳米）识别。这些纳米颗粒可以通过DNA链置换按需选择性地擦除或重写。
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