Qin Xian-Yun, Lin Lin, Yang Yan, Zhang Shu-Xiang, Kong Jian-Qiang, Cheng Ke-Di, Zhao Yun-Feng, Wang Wei
College of Life Science, Qufu Normal University, Qufu 273165, China.
Yao Xue Xue Bao. 2011 Jul;46(7):753-61.
Human enterovirus 71 (EV71) is one of the major etiological agents for the hand, foot, and month disease (HFMD) and is causing frequent, widespread occurrence in the mainland of China. The single positive-stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins. The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication. This article reviews the studies of the structures and functions of nonstructural proteins of EV71 and the anti-enterovirus 71 drugs targeting on these nonstructural proteins.
人肠道病毒71型（EV71）是手足口病（HFMD）的主要病原体之一，在中国内地频繁广泛流行。EV71的单正链RNA基因组被翻译成一个单一的多聚蛋白，该多聚蛋白会自动切割成结构蛋白和非结构蛋白。许多在病毒生命周期中具有特征的非结构蛋白的功能是阻断病毒复制的潜在靶点。本文综述了EV71非结构蛋白的结构和功能以及针对这些非结构蛋白的抗肠道病毒71型药物的研究。
