Kujawa Anna, Kostek Halina, Szponar Jarosław, Majewska Magdalena, Ossowska Beata
Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej.
Przegl Lek. 2011;68(8):530-2.
The paper presents the case of a female, 36, hospitalised in the Lublin Regional Center of Clinical Toxicology, diagnosed with heavy ethylene glycol intoxication. The patient suffered from metabolic acidosis with pH at 6.6, bases shortage - 35,5 mmol/l, renal failure, acute respiratory failure, symptoms of CNS damage such as prolonged coma, followed by dysphasia and the lower limbs paresis persisting for a few weeks. During the treatment, ethanol was used as a competitive inhibitor of alcoholic dehydrogenase along with hemodialyses, intensive symptomatic treatment, care and rehabilitation. In spite of the severe course of the intoxication, the procedures employed with the patient resulted turned out to be effective, with total renal failure regression, lower limb paresis regression, speech function regain and regular motor apparatus function regain and the regaining of speech and regular motor apparatus functions. The case description proves that intensive therapy might lead to recovery even in cases of extreme metabolic acidosis.
本文介绍了一名36岁女性的病例，该患者在卢布林地区临床毒理学中心住院，被诊断为重度乙二醇中毒。患者患有代谢性酸中毒，pH值为6.6，碱缺乏-35.5 mmol/l，肾衰竭，急性呼吸衰竭，出现中枢神经系统损伤症状，如长时间昏迷，随后出现吞咽困难和下肢轻瘫，持续数周。治疗期间，使用乙醇作为乙醇脱氢酶的竞争性抑制剂，同时进行血液透析、强化对症治疗、护理和康复治疗。尽管中毒过程严重，但对该患者采用的治疗措施被证明是有效的，出现了完全性肾衰竭消退、下肢轻瘫消退、言语功能恢复以及常规运动功能恢复。病例描述证明，即使在极端代谢性酸中毒的情况下，强化治疗也可能导致康复。
