印度德里心血管危险因素的一项研究。

A study of cardiovascular risk factors in Delhi, India.

作者信息

Grover Gurprit, Gadpayle A K, Dutta Rumi

机构信息

Department of Statistics, University of Delhi, Delhi-110007, India.

出版信息

J Commun Dis. 2009 Jun;41(2):71-80.

PMID:22010494

Abstract

Acute myocardial infarction (AMI) is a leading cause of mortality and disability of adults in urban and rural India, and occurs at younger age than in western populations. In this paper an attempt has been made to determine the risk factors for non- fatal AMI among Indian men and women and to study the difference in proportion of risk factors by taking non- AMI group along with healthy group as controls. Mantel Haenzel test showed that while comparing AMI with non-AMI group, diabetes mellitus (p < 0.05), family history of MI (p < 0.0001) and smoking (p < 0.0001) are significantly associated with AMI after adjusting the effects of hypertension. The same test was carried out in comparing AMI with healthy group which showed that diabetes mellitus (p < 0.05), family history of MI (p < 0.0001) and smoking (p < 0.0001) are significantly associated with AMI after adjusting the effects of hypertension. Similarly, while comparing CVD group with healthy group, family history of MI (p < 0.0001) and smoking (p < 0.0001) are significantly associated with CVD after adjusting the effects of hypertension. Stepwise logistic regression showed that while comparing AMI cases with non- AMI controls, arrhythmias (odds ratio (OR) = 5.196, p < 0.0001), angina (OR = 3.599, p < 0.0001), CHF (OR = 3.121, p < 0.0001), hypertension (OR = 2.717, p < 0.0001), smoking (OR = 1.993, p < 0.0001) and family history of MI (OR = 1.819, p < 0.01) were important risk factors for a first myocardial infarction. Moreover, while comparing AMI cases with healthy controls, family history of AMI (OR = 15.925, p < 0.0001), smoking (OR = 2.806, p < 0.001), hypertension (OR = 2.718, p < 0.0001), gender (OR = 2.410, p < 0.01) and age (OR = 2.410, p < 0.05) were important predictors of AMI; and while comparing CVD cases (AMI and non-AMI) with healthy group, family history of MI (OR = 10.377, p < 0.01), hypertension (OR = 8.237, p < 0.01) and smoking (OR = 4.454, p < 0.01), were important predictors of cardiovascular disease.

摘要

急性心肌梗死（AMI）是印度城乡成年人死亡和残疾的主要原因，且发病年龄比西方人群更年轻。本文试图确定印度男性和女性非致命性AMI的危险因素，并通过将非AMI组和健康组作为对照来研究危险因素比例的差异。Mantel Haenzel检验表明，在将AMI与非AMI组进行比较时，在调整高血压影响后，糖尿病（p < 0.05）、心肌梗死家族史（p < 0.0001）和吸烟（p < 0.0001）与AMI显著相关。在将AMI与健康组进行比较时进行了相同的检验，结果表明在调整高血压影响后，糖尿病（p < 0.05）、心肌梗死家族史（p < 0.0001）和吸烟（p < 0.0001）与AMI显著相关。同样，在将心血管疾病（CVD）组与健康组进行比较时，在调整高血压影响后，心肌梗死家族史（p < 0.0001）和吸烟（p < 0.0001）与CVD显著相关。逐步逻辑回归表明，在将AMI病例与非AMI对照进行比较时，心律失常（优势比（OR） = 5.196，p < 0.0001）、心绞痛（OR = 3.599，p < 0.0001）、充血性心力衰竭（CHF）（OR = 3.121，p < 0.0001）、高血压（OR = 2.717，p < 0.0001）、吸烟（OR = 1.993，p < 0.0001）和心肌梗死家族史（OR = 1.819，p < 0.01）是首次心肌梗死的重要危险因素。此外，在将AMI病例与健康对照进行比较时，急性心肌梗死家族史（OR = 15.925，p < 0.0001）、吸烟（OR = 2.806，p < 0.001）、高血压（OR = 2.718，p < 0.0001）、性别（OR = 2.410，p < 0.01）和年龄（OR = 2.410，p < 0.05）是AMI的重要预测因素；而在将CVD病例（AMI和非AMI）与健康组进行比较时，心肌梗死家族史（OR = 10.377，p < 0.01）、高血压（OR = 8.237，p < 0.01）和吸烟（OR = 4.454，p < 0.01）是心血管疾病的重要预测因素。