Cignini Pietro, Mobili Luisa, D'Emidio Laura, Mangiafico Lucia, Coco Claudio, Giorlandino Claudio
Department of Prenatal Diagnosis, Artemisia Fetal-Maternal Medical Center, Rome, Italy.
J Reprod Med. 2011 Sep-Oct;56(9-10):393-7.
To compare the abortion rate and preterm premature rupture of membranes (PPROM) after amniocentesis in women who have undergone antibiotic prophylaxis with uterine fibroids and control.
Retrospective study using the Antibiotic Prophylaxis before Second-Trimester Genetic Amniocentesis trial database carried out between January 1999 and December 2005 at the Artemisia Fetal-Maternal Medical Center (Rome, Italy). All women underwent antibiotic prophylaxis before amniocentesis. A follow-up within 4 weeks from the procedure was available.
A total of 2,497 of 21,219 (11.8%) women with uterine fibroids were identified. The rate of abortion was 2 of 2,497 (0.08%) in women with fibroids and 4 of 18,722 (0.03%) in women without fibroids (p = 0.42). The rate of PPROM was 4 of 2,497 (0.16%) in women with fibroids and 10 of 18,722 (0.05%) in women without fibroids (p = 0.12).
The risk for abortion and PPROM does not increase in the presence of uterine fibroids in women who have undergone antibiotic prophylaxis.
比较接受抗生素预防的子宫肌瘤女性与对照组女性在羊膜腔穿刺术后的流产率和胎膜早破（PPROM）情况。
回顾性研究，使用1999年1月至2005年12月在意大利罗马蒿属母婴医学中心进行的孕中期遗传羊膜腔穿刺术前抗生素预防试验数据库。所有女性在羊膜腔穿刺术前均接受了抗生素预防。可获得术后4周内的随访结果。
在21219名女性中，共识别出2497名（11.8%）患有子宫肌瘤。子宫肌瘤女性的流产率为2497例中的2例（0.08%），无子宫肌瘤女性的流产率为18722例中的4例（0.03%）（p = 0.42）。子宫肌瘤女性的PPROM发生率为2497例中的4例（0.16%），无子宫肌瘤女性的PPROM发生率为18722例中的10例（0.05%）（p = 0.12）。
接受抗生素预防的女性，子宫肌瘤的存在不会增加流产和PPROM的风险。
