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胆囊类癌肿瘤——一例报告

Carcinoid tumour of gall bladder--a case report.

作者信息

Ghosh Mriganka, Bhattacharyya Nirmal Kumar, Ghoshsengupta Soumita

机构信息

Department of Pathology, North Bengal Medical College and Hospital Sushrutanagar 734012.

出版信息

J Indian Med Assoc. 2011 Mar;109(3):198-9.

Abstract

Gall bladder carcinoid tumours are rare, constituting less than 1% of all carcinoid tumours arising from different parts of the body. They usually lack specific symptoms as they typically are unassociated with the carcinoid syndrome, despite frequent hepatic spread and mostly detected after cholecystectomy. A case of gall bladder carcinoid is reported in a 35-year-old woman who underwent laparoscopic cholecystectomy for clinical features of cholelithiasis. Several comparative evaluation was attempted mainly between the carcinoid and variant groups (endocrinomas) and occasionally between the typical and atypical carcinoid series to solve the existing serious problem in categorisation of this group of tumours. While the usual criteria for judging malignancy, such as anaplasia and mitotic figures, are unreliable in these sites of carcinoid tumour, malignancy is well determined from evidence of tumour invasion into adjacent structures. This rarity and the ambiguity around it stresses for its documentation and warrants for international agreements and standards on basic criteria for such classification of these endocrine carcinomas.

摘要

胆囊类癌肿瘤较为罕见,占全身不同部位发生的所有类癌肿瘤的比例不到1%。它们通常缺乏特异性症状,因为尽管常有肝转移且大多在胆囊切除术后才被发现,但通常与类癌综合征无关。本文报告了一例35岁女性胆囊类癌病例,该患者因胆囊结石临床表现接受了腹腔镜胆囊切除术。主要在类癌与变异组(内分泌瘤)之间进行了多项比较评估,偶尔也在典型类癌和非典型类癌系列之间进行比较,以解决这组肿瘤分类中存在的严重问题。虽然判断恶性肿瘤的常用标准,如间变和有丝分裂象,在这些类癌肿瘤部位并不可靠,但从肿瘤侵犯相邻结构的证据可以很好地确定恶性程度。这种罕见性及其周围的模糊性强调了对其进行记录的必要性,并需要就这些内分泌癌此类分类的基本标准达成国际协议和标准。

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