Soga J
The Niigata Seiryo University, Niigata City, Niigata, Japan.
J Exp Clin Cancer Res. 2002 Dec;21(4):457-68.
This study was undertaken to evaluate the statistical results of a large collected series of primary hepatic endocrinomas including carcinoids from extensive clinicopathologic aspect, and to provide the information to investigators engaged in this particular field of research. Primary hepatic endocrinomas variously termed as endocrine cell carcinoma (ECC), neuroendocrine carcinoma (NEC), carcinoid, and other carcinomas with endocrine components (CECs), have been rarely reported in literature. A total of 126 reported cases were registered in the Niigata Registry for gut-pancreatic endocrinomas. They consisted of a carcinoid group with typical carcinoids (n=82) and atypical carcinoids (n=19) and another group with other variant endocrinomas, briefly expressed as the variant group (n=25) in this study. The number of females was larger than that of males in the carcinoid group (M/F=0.58) and reversely males were predominant in the variant group (M/F=1.78). The average age was considerably older in the carcinoid group as compared to that in the variant group (53.9 years vs 48.3 years). The carcinoid group (either typical, atypical or both) showed a significant lower value than the variant group in metastasis rates in the large (over 50 mm) tumor series (43.3% vs 75.0%: P<0.05), and higher than the latter in serotonin positivity demonstrated by immunohistochemistry (37.0% vs 11.1%). While no significant difference was present between the two groups, cases with large tumors over 50 mm were found at a high rate (P<0.01) in approximately three fourths of each group, i.e. 76 out of a total of 100 cases recorded, and the liver was more often involved by metastasis than lymph nodes in the carcinoid group (32.7% vs 19.8%: P<0.05) though no significant difference was noted between these two sites in the variant group. The five-year survival rates calculated by the Kaplan-Meier method showed better results in the carcinoid group than in the variant group but with no statistically significant difference (92.4% vs 68.1%). A close similarity found in many aspects of the two groups suggested endocrinomas in the present study apparently belong to one family of CECs or briefly "carcinoid family". Regarding the more detailed statistical analyses, further accumulation of well-documented cases is needed.
本研究旨在从广泛的临床病理角度评估大量收集的原发性肝内分泌瘤（包括类癌）的统计结果，并为从事该特定研究领域的研究人员提供相关信息。原发性肝内分泌瘤有多种称谓，如内分泌细胞癌（ECC）、神经内分泌癌（NEC）、类癌以及其他具有内分泌成分的癌（CEC），在文献中鲜有报道。新潟胃肠胰内分泌瘤登记处共登记了126例报告病例。它们包括一个类癌组，其中典型类癌（n = 82）和非典型类癌（n = 19），以及另一组其他变异内分泌瘤，在本研究中简称为变异组（n = 25）。类癌组中女性数量多于男性（男/女 = 0.58），而变异组中男性占主导（男/女 = 1.78）。与变异组相比，类癌组的平均年龄明显更大（53.9岁对48.3岁）。在大肿瘤（超过50 mm）系列中，类癌组（包括典型、非典型或两者）的转移率显著低于变异组（43.3%对75.0%：P<0.05），而免疫组化显示类癌组的血清素阳性率高于变异组（37.0%对11.1%）。虽然两组之间没有显著差异，但在每组约四分之三的病例中发现大肿瘤（超过50 mm）的发生率较高（P<0.01），即在总共记录的100例病例中有76例，并且在类癌组中肝脏转移比淋巴结转移更常见（32.
