Division of Forest Insect Pests and Diseases, Korea Forest Research Institute, Republic of Korea.
Nat Prod Res. 2012;26(22):2129-31. doi: 10.1080/14786419.2011.628178. Epub 2011 Oct 20.
The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 µg/♀) followed by guineensine (1.9 µg/♀), retrofractamide A (2.4 µg/♀) and pipercide (3.2 µg/♀). LD(50) value of chlorpyrifos was 0.03 µg/♀. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 µg/♀) than in retrofractamide A (1.5 µg/♀), guineensine (1.7 µg/♀), and pipercide (2.0 µg/♀). LD(50) value of chlorpyrifos was 0.0014 µg/♀.
胡椒科胡椒属果实衍生哌啶生物碱（胡椒碱）和 N-异丁基酰胺生物碱（胡椒乙胺、瓜里宁、胡椒酰胺和反式裂环酰胺 A）对致倦库蚊和埃及伊蚊雌成蚊的杀虫活性进行了研究。根据 24 小时 LD50 值，对雌性致倦库蚊毒性最高的化合物是胡椒乙胺（0.4µg/♀），其次是瓜里宁（1.9µg/♀）、反式裂环酰胺 A（2.4µg/♀）和胡椒酰胺（3.2µg/♀）。毒死蜱的 LD50 值为 0.03µg/♀。对雌性埃及伊蚊，胡椒乙胺（0.17µg/♀）的杀虫活性强于反式裂环酰胺 A（1.5µg/♀）、瓜里宁（1.7µg/♀）和胡椒酰胺（2.0µg/♀）。毒死蜱的 LD50 值为 0.0014µg/♀。
