胡椒堿，一种针对 HL6 和 MCT-7 细胞系的潜在抗癌先导化合物，以及从黑胡椒中微生物转化胡椒堿。

Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum.

机构信息

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia.

出版信息

Molecules. 2010 Apr 5;15(4):2398-404. doi: 10.3390/molecules15042398.

DOI:10.3390/molecules15042398

PMID:20428051

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257300/

Abstract

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

摘要

胡椒堿（1），从胡椒属植物根部分离得到，对 HL60 和 MCT-7 细胞系表现出强烈的细胞毒性。胡椒堿（2）的微生物转化得到了一种新化合物 5-[3,4-(亚甲二氧基)苯基]-戊-2-烯哌啶（3）。还从胡椒属植物中发现了另外两种生物碱。它们是（E）-1-[3',4'-(亚甲二氧基)肉桂酰基]哌啶（4）和 2,4-十四碳二烯酸异丁酰胺（5）。这些化合物是通过色谱方法分离得到的，并通过 MS、IR 和 NMR 技术阐明了它们的结构。