Department of Chemistry, Division of Molecular Imaging and Photonics, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Langmuir. 2011 Nov 15;27(22):13598-605. doi: 10.1021/la203410k. Epub 2011 Oct 19.
Molecular patterning has received a lot of attention in the past decade; however, the functionalization of these surface-confined 2D patterns on the nanoscale level remains a challenge. Assembling 2D patterns from oligomeric foldamers turns out to be an interesting approach to accomplishing the controlled positioning of functional elements. We designed a family of peptidomimetic foldamers bearing a 2D turn element folding at the liquid/solid interface. The turning element was developed while studying derivatives with one turning unit. Furthermore, folding was found to be induced by the confinement of the surface. This achievement paves the way for the design of foldamers with multiple turns, providing a higher versatility in the functionalization of nanopatterns.
在过去的十年中，分子模式受到了广泛关注；然而，在纳米尺度上对这些表面受限的二维图案进行功能化仍然是一个挑战。通过将低聚物折叠体组装成二维图案，从而实现对功能元件的可控定位，这是一种很有前途的方法。我们设计了一系列具有二维转角元件的肽模拟折叠体，该转角元件在研究具有一个转角单元的衍生物时被发现。此外，折叠是由表面的限制诱导的。这一成就为设计具有多个转角的折叠体铺平了道路，为纳米图案的功能化提供了更高的通用性。
