后部皮质萎缩：独特特征。
Posterior cortical atrophy: Unique features.
作者信息
Tom T, Cummings J L, Pollak J
机构信息
a Department of Neurology , Los Angeles , CA , 90095-1769 , USA.
出版信息
Neurocase. 1998 Jan;4(1):15-20. doi: 10.1080/13554799808410603.
Abstract Posterior cortical atrophy (PCA) is a visual-cognitive syndrome caused by Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), or subcortical gliosis. We report a case of posterior cortical atrophy unique in (1) comprehensive documentation of clinical, radiologic, electroencephalograph, metabolic and histopathologic findings, (2) repeated clinical and laboratory assessment, and (3) establishment of unique occipital subcortical gliosis in a patient with AD. Clinical manifestations of PCA caused by AD included visual agnosia, cortical blindness, optic apraxla, delusions, hallucinations, agitation, depression, amnestic deficit, Wernicke's aphasia, acalculia, and left/right disorientation. Posterior cortical atrophy produced by AD can be demonstrated on magnetic resonance imaging, positron emission tomography, and electroencephalography; determination of the etiology requires tissue examination. Autopsy-diagnosed cases in the literature document PCA due to CJD and AD with equal frequency.
摘要 后部皮质萎缩（PCA）是一种由克雅氏病（CJD）、阿尔茨海默病（AD）或皮质下胶质增生引起的视觉认知综合征。我们报告了一例后部皮质萎缩病例，该病例具有以下独特之处：（1）全面记录了临床、放射学、脑电图、代谢和组织病理学检查结果；（2）进行了多次临床和实验室评估；（3）在一名AD患者中发现了独特的枕叶皮质下胶质增生。AD所致PCA的临床表现包括视觉失认、皮质盲、视性失用、妄想、幻觉、激越、抑郁、遗忘缺陷、韦尼克失语、失算以及左右定向障碍。AD导致的后部皮质萎缩可通过磁共振成像、正电子发射断层扫描和脑电图显示；病因的确定需要进行组织检查。文献中经尸检诊断的病例显示，CJD和AD导致PCA的频率相同。
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