Wakai M, Honda H, Takahashi A, Kato T, Ito K, Hamanaka T
Department of Neurology, Nagoya University School of Medicine, Japan.
Acta Neurol Scand. 1994 Jun;89(6):458-61. doi: 10.1111/j.1600-0404.1994.tb02666.x.
We present a patient with posterior cortical atrophy in whom positron emission tomography (PET) showed unusual findings. This 65-year-old man had a 5-year history of slowly progressive apperceptive visual agnosia and Balint syndrome, but with a relatively well-preserved intelligence and language ability even in the later stages of illness. No relevant features in this patient or his family were identified. Laboratory and radiographic investigations indicated that cerebral damage was due to primary degeneration. His symptoms resembled those of patients with posterior cortical atrophy. A PET study revealed that cerebral metabolism was reduced in the dorsal regions of the entire cortex and asymmetrical with the main site of damage on the right. The severity in asymmetry increased dorsally. These 2 types of predilection for dorsal regions had not previously been reported in such patients. These unusual PET findings may indicate the presence of pathological changes not yet identified.
我们报告了一名患有后皮质萎缩的患者，其正电子发射断层扫描（PET）显示出异常结果。这名65岁男性有5年缓慢进展的统觉性视觉失认和 Balint 综合征病史，但即使在疾病后期，其智力和语言能力相对保留较好。未发现该患者及其家族有相关特征。实验室和影像学检查表明，脑损伤是由原发性变性引起的。他的症状与后皮质萎缩患者相似。一项PET研究显示，整个皮质背侧区域的脑代谢降低，且与右侧主要损伤部位不对称。不对称的严重程度在背侧增加。此前尚未在这类患者中报道过这两种对背侧区域的偏好类型。这些异常的PET结果可能表明存在尚未明确的病理变化。
