P16INK4A 过表达可预测宫颈癌的淋巴结转移。

P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas.

机构信息

Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

出版信息

J Clin Pathol. 2012 Feb;65(2):117-21. doi: 10.1136/jclinpath-2011-200362. Epub 2011 Oct 19.

DOI:10.1136/jclinpath-2011-200362

PMID:22011452

Abstract

BACKGROUND

The p16(INK4A) protein (p16) is a cyclin-dependent kinase inhibitor that arrests the cell cycle in the G1 phase.

AIM

To explore the potential of p16 as a predictive marker for lymph node (LN) metastasis and prognosis in cervical carcinomas.

METHODS

145 patients diagnosed with FIGO stage I to IV cervical carcinoma were studied; 95 underwent LN dissection. The expression of p16 protein was studied by immunohistochemistry using tissue microarrays.

RESULTS

Overexpression of p16 was seen in 108 of 145 (74.5%) invasive carcinomas. There was a significant correlation between p16 expression and LN metastasis (p=0.007). Patients with p16 overexpression had poorer survival than patients with p16 underexpression (59.3% vs 83.8% 5-year survival rate, log-rank p=0.015). In univariate analysis, p16 expression was a significant predictor of survival (RR 2.76, p=0.02).

CONCLUSIONS

Results suggest that p16 expression is an important predictive factor of LN metastasis in cervical cancer patients. Moreover, p16 overexpression is associated with a poor prognosis. Therefore, immunohistochemical evaluation of p16 expression is of potential value for treatment planning in cervical carcinomas.

摘要

背景

p16（INK4A）蛋白（p16）是一种细胞周期蛋白依赖性激酶抑制剂，可使细胞周期在 G1 期停滞。

目的

探讨 p16 作为预测宫颈癌淋巴结（LN）转移和预后的标志物的潜力。

方法

研究了 145 例诊断为 FIGO Ⅰ至Ⅳ期宫颈癌的患者；其中 95 例行 LN 解剖。使用组织微阵列通过免疫组织化学研究 p16 蛋白的表达。

结果

在 145 例浸润性癌中，有 108 例（74.5%）出现 p16 过表达。p16 表达与 LN 转移之间存在显著相关性（p=0.007）。p16 过表达的患者比 p16 低表达的患者生存率差（5 年生存率分别为 59.3%和 83.8%，log-rank p=0.015）。在单因素分析中，p16 表达是生存的显著预测因子（RR 2.76，p=0.02）。