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斑秃:儿科皮肤科回顾性研究(2000 - 2008年)

[Alopecia areata: a retrospective study of the paediatric dermatology department (2000-2008)].

作者信息

Rocha Joana, Ventura Filipa, Vieira Ana Paula, Pinheiro Ana Raquel, Fernandes Susana, Brito Celeste

机构信息

Serviço de Dermatologia, Hospital de São Marcos, Braga, Portugal.

出版信息

Acta Med Port. 2011 Mar-Apr;24(2):207-14. Epub 2011 May 20.

Abstract

INTRODUCTION

Alopecia areata usually presents as patchy, nonscarring hair loss. It seems to be an immune mediated disease, whereas genetic predisposition, environmental and psychological triggers may be involved in its aetiology.

OBJECTIVES

To study the epidemiology, clinical aspects, associations, and treatment of alopecia areata in the paediatric population of Peadiatric Dermatology outpatients over a 9-year period. Some psychologic characteristics were also assessed.

METHODS

Descriptive and retrospective study of all newly diagnosed AA cases seen from January 2000 to December 2008 at the Hospital de São Marcos' Paediatric Dermatology Department. Fifteen patients with AA were interviewed for psycologic evaluation.

RESULTS

Forty-eight cases (54% male/46% female) were identified. Mean age at presentation was 7.8 years. Family history of AA was reported in 10% of the cases, and in 25% there was a personal and/or family history of atopy. The majority of patients (82%) had mild disease and topical corticotherapy was the first-line treatment for limited AA. Fifty-four percent of these patients had a complete resolution of the lesions with treatment. Systemic treatment (corticosteroids and/or ciclosporin) was used in 71% of patients with extensive disease (more than 50% hair loss). Only one of these patients had a sustained clinical improvement after treatment. Twelve out of 15 respondents (80%) recalled stressful events preceding hair loss.

DISCUSSION

Our findings are similar to those reported in other studies. Epidemiologic studies of AA are available in adulthood but there is a paucity of literature on children with AA. A holistic approach is important in the management of childhood AA as the disease can have a severe psychologic impact on an individual's well-being.

摘要

引言

斑秃通常表现为片状、非瘢痕性脱发。它似乎是一种免疫介导的疾病,而遗传易感性、环境和心理触发因素可能参与其病因。

目的

研究9年间儿科皮肤科门诊儿童斑秃的流行病学、临床特征、相关因素及治疗。还评估了一些心理特征。

方法

对2000年1月至2008年12月在圣马科斯医院儿科皮肤科新诊断的所有斑秃病例进行描述性回顾性研究。对15例斑秃患者进行心理评估访谈。

结果

共确诊48例(男性54%/女性46%)。就诊时的平均年龄为7.8岁。10%的病例有斑秃家族史,25%有个人和/或家族过敏史。大多数患者(82%)病情较轻,局部皮质类固醇疗法是局限性斑秃的一线治疗方法。这些患者中有54%在治疗后皮损完全消退。71%的广泛性疾病(脱发超过50%)患者使用了全身治疗(皮质类固醇和/或环孢素)。这些患者中只有1例在治疗后有持续的临床改善。15名受访者中有12名(80%)回忆起脱发前有压力事件。

讨论

我们的研究结果与其他研究报告的结果相似。斑秃的流行病学研究在成人中有,但关于儿童斑秃的文献很少。在儿童斑秃的管理中,整体方法很重要,因为这种疾病可能对个人的幸福感产生严重的心理影响。

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