Department of Cardiology, Second University of Naples-Monaldi Hospital, Naples, Italy.
J Investig Med. 2011 Oct;59(7):1151-4. doi: 10.2310/JIM.0b013e31822cf97a.
Paroxysmal episodes of atrial fibrillation frequently occur in Emery-Dreifuss muscular dystrophy (EDMD). Although previous studies have documented a variety of electrocardiographic abnormalities in EDMD, little is still known about P-wave dispersion (PD), an independent risk factor for the development of atrial fibrillation. The aim of our study was to evaluate the P-wave duration and PD in patients with EDMD with conserved systolic and diastolic cardiac function.
The study involved 36 patients with EDMD (age, 20 [SD, 12] years; 26 men) and 36 healthy subjects used as controls, matched for age and sex. P-wave dispersion was carefully measured using 12-lead electrocardiogram. Compared with the healthy control group, patients with EDMD presented increased maximum P-wave duration (108.2 [SD, 22.2] vs 97.8 [SD, 11] milliseconds, P = 0.04) and PD (51.4 [SD, 12.8] vs 39.3 [SD, 9.7] milliseconds, P = 0.004) values. No statistically significant differences in left atrium diameter (37.1 [SD, 2.9] vs 34.1 [SD, 4.2] mm, P = 0.3) and maximum left atrium volume (15.2 [SD, 3.8] vs 14.1 [SD, 4.2] mL/m2, P = 0.4) were found between the 2 groups. We divided our study population into 2 subgroups, according to the different genetic diagnosis, patients with laminopathy EDMD (n = 17) or with emerinopathy EDMD (n = 19). No statistically significant differences were found in PD between the 2 subgroups (54.6 [SD, 15.6] vs 50.2 [SD, 11.5] milliseconds, P = 0.4).
Our study showed a significant increase of maximum P-wave duration and PD in patients with EDMD with conserved systolic and diastolic cardiac function.
阵发性心房颤动在 Emery-Dreifuss 肌营养不良症（EDMD）中经常发生。尽管以前的研究已经记录了 EDMD 中的各种心电图异常，但对于 P 波离散度（PD）知之甚少，PD 是心房颤动发展的独立危险因素。我们的研究目的是评估在心脏收缩和舒张功能正常的 EDMD 患者中的 P 波持续时间和 PD。
该研究共纳入 36 名 EDMD 患者（年龄 20 [标准差 12] 岁；26 名男性）和 36 名健康对照者，年龄和性别相匹配。使用 12 导联心电图仔细测量 P 波离散度。与健康对照组相比，EDMD 患者的最大 P 波持续时间（108.2 [标准差 22.2] 与 97.8 [标准差 11] 毫秒，P = 0.04）和 PD（51.4 [标准差 12.8] 与 39.3 [标准差 9.7] 毫秒，P = 0.004）值增加。两组间左心房直径（37.1 [标准差 2.9] 与 34.1 [标准差 4.2] 毫米，P = 0.3）和最大左心房容积（15.2 [标准差 3.8] 与 14.1 [标准差 4.2] 毫升/平方米，P = 0.4）无统计学差异。我们根据不同的基因诊断将研究人群分为 2 个亚组， laminopathy EDMD 患者（n = 17）或 emerinopathy EDMD 患者（n = 19）。2 个亚组之间 PD 无统计学差异（54.6 [标准差 15.6] 与 50.2 [标准差 11.5] 毫秒，P = 0.4）。
我们的研究表明，在心脏收缩和舒张功能正常的 EDMD 患者中，最大 P 波持续时间和 PD 显著增加。
