La Sapienza University, Rome, Italy.
Clin Exp Rheumatol. 2011 Nov-Dec;29(6 Suppl 69):S49-54. Epub 2012 Jan 3.
Fibromyalgia (FM) is a generalized chronic pain condition that is often accompanied by symptoms such as fatigue, sleep disturbances, psychological and cognitive alterations, headache, migraine, variable bowel habits, diffuse abdominal pain, and urinary frequency. Its key assessment domains include pain, fatigue, disturbed sleep, physical and emotional functioning, and patient global satisfaction and health-related quality of life (HRQL). A number of evaluation measures have been adapted from the fields of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, and others such as the Fibromyalgia Assessment Status (FAS) index and the Fibromyalgia Impact Questionnaire (FIQ) have been specifically developed. The aim of this study was to assess the impact of FM on HRQL by comparing the performance of the FAS index, the FIQ and the Health Assessment Questionnaire [HAQ] in 541 female and 31 male FM patients (mean age 50 years; mean disease duration 7.7 years) entered in the database of a web-based survey registry developed by the Italian Fibromyalgia Network (IFINET). Tests of convergent validity showed that the FAS index and FIQ significantly correlated with each other (rho=0.608, p<0.0001), but there were also significant correlations between the FAS index and other clinical measures of disability, including the HAQ (rho=0.423, p<0.0001), anxiety (rho=0.138, p=0.0009), depression (rho=0.174, p<0.0001) and, especially, the number of comorbidities (rho=0.147, p=0.0004). The FAS index revealed a statistically significant difference between males and females (p=0.048), analysed using the Mann-Whitney U-test for all pair wise comparisons. The FAS index is a valid three-item instrument (pain, fatigue and sleep disturbances) that performs at least as well as the FIQ in FM patients, and is simpler to administer and score. Both questionnaires may be useful when screening FM patients, with the choice of the most appropriate instrument depending on the setting.
纤维肌痛（FM）是一种全身性慢性疼痛疾病，常伴有疲劳、睡眠障碍、心理和认知改变、头痛、偏头痛、肠道习惯改变、弥漫性腹痛和尿频等症状。其主要评估领域包括疼痛、疲劳、睡眠障碍、身体和情绪功能以及患者整体满意度和健康相关生活质量（HRQL）。许多评估措施是从类风湿关节炎、银屑病关节炎和强直性脊柱炎等领域改编而来的，还有一些特定的措施，如纤维肌痛评估状态（FAS）指数和纤维肌痛影响问卷（FIQ）。本研究旨在通过比较 FAS 指数、FIQ 和健康评估问卷[HAQ]在 541 名女性和 31 名男性纤维肌痛患者（平均年龄 50 岁；平均病程 7.7 年）中的表现，评估 FM 对 HRQL 的影响，这些患者纳入了由意大利纤维肌痛网络（IFINET）开发的基于网络的调查登记处的数据库。收敛效度检验表明，FAS 指数和 FIQ 显著相关（rho=0.608，p<0.0001），但 FAS 指数与其他残疾临床指标，包括 HAQ（rho=0.423，p<0.0001）、焦虑（rho=0.138，p=0.0009）、抑郁（rho=0.174，p<0.0001）和尤其，共病数量（rho=0.147，p=0.0004）也有显著相关性。FAS 指数在男性和女性之间存在统计学差异（p=0.048），使用 Mann-Whitney U 检验进行所有两两比较。FAS 指数是一种有效的三项工具（疼痛、疲劳和睡眠障碍），在 FM 患者中的表现至少与 FIQ 一样好，并且更易于管理和评分。这两种问卷在筛选 FM 患者时都可能有用，具体选择哪种最合适的工具取决于具体情况。
