Aktüre E, Salamat M S, Korkmaz H, Baskaya M K
Department of Neurological Surgery, and Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Clin Neuropathol. 2011 Nov-Dec;30(6):313-7. doi: 10.5414/np300376.
Ganglioneuromas (GNs) are well-differentiated, slow-growing, benign tumors that are quite rare and usually found in the posterior mediastinum and retroperitoneum. They are composed of ganglion and Schwann cells and their origin remains in dispute. GNs have been reported as intraosseous lesions, such as in temporal and orbital bones. There are rare reports of intracranial lesions, mostly in the pituitary fossa. Most GN patients are children and are clinically asymptomatic. Diagnosis of GN requires histopathologic evaluation since no specific clinical or radiologic diagnostic features have been identified. We report the case of a 35-year-old man with recurrent sinusitis whose radiologic workup revealed a lytic right sphenoid wing lesion with microcalcifications. He underwent gross-total resection of the lesion and the pathologic findings were diagnostic of ganglioneuroma. To the best of our knowledge, this is the first reported case of sphenoid wing GN. The nature and origin of this tumor are discussed, and the GN literature is reviewed.
神经节神经瘤（GNs）是一种分化良好、生长缓慢的良性肿瘤，非常罕见，通常位于后纵隔和腹膜后。它们由神经节细胞和施万细胞组成，其起源仍存在争议。GNs 已被报道为骨内病变，如颞骨和眶骨。颅内病变的报道很少，大多位于垂体窝。大多数 GN 患者为儿童，临床上无症状。由于尚未发现特异性的临床或放射学诊断特征，GN 的诊断需要组织病理学评估。我们报告一例 35 岁复发性鼻窦炎男性患者，其影像学检查发现右侧蝶骨翼有溶骨性病变并伴有微钙化。他接受了病变的全切除，病理结果诊断为神经节神经瘤。据我们所知，这是首例报道的蝶骨翼 GN 病例。本文讨论了该肿瘤的性质和起源，并对 GN 的文献进行了综述。
