Cunha Danilo da Silva, Simões Maria Izilda Previato, Viviani Dionísio Nepomuceno, Boldrini Domingos, Rocha Euclides Timóteo da, Morini Sandra Regina, Moriguchi Sonia Marta
Department Nuclear Medicine, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
Arq Bras Endocrinol Metabol. 2011 Aug;55(6):419-25. doi: 10.1590/s0004-27302011000600009.
Radioiodine therapy for patients with differentiated thyroid cancer aims at reducing tumor recurrence by eradicating residual macro- and microscopic foci. Side effects are generally rare, tenuous and transient, with little clinical significance.
To report a rare case of differentiated thyroid carcinoma presenting a large expansive solid mass at the base of the skull, with invasion of the left masticatory muscle and adjacent subcutaneous tissue, and without invasion of the carotid space, which evolved to carotid artery rupture following radioiodine therapy.
Side effects are uncommon after radioiodine therapy and when present, have mild intensity. Serious adverse events are very rare, especially those arising from structures not directly invaded by metastatic tissue with radioiodine uptake, as occurred in this case. This occurrence serves to raise awareness of the need for increased care when using radioiodine therapy on high-avidity masses located close to important structures.
分化型甲状腺癌患者的放射性碘治疗旨在通过根除残留的大体和微小病灶来降低肿瘤复发率。副作用通常罕见、轻微且短暂，临床意义不大。
报告一例罕见的分化型甲状腺癌病例，该病例在颅底出现一个巨大的实性肿块，侵犯左侧咀嚼肌及相邻皮下组织，但未侵犯颈动脉间隙，在放射性碘治疗后演变为颈动脉破裂。
放射性碘治疗后副作用并不常见，即便出现，程度也较轻。严重不良事件非常罕见，尤其是像本例这样由未被放射性碘摄取的转移组织直接侵犯的结构所引发的事件。这一病例提醒人们，对于靠近重要结构的高摄取肿块进行放射性碘治疗时，需提高警惕。
