Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Chem Commun (Camb). 2011 Dec 7;47(45):12316-8. doi: 10.1039/c1cc14916d. Epub 2011 Oct 20.
A new strategy for the rapid construction of functionalized reduced indoles starting from activated methylene isocyanides and 1,5-dielectrophilic 5-oxohepta-2,6-dienoates (and their equivalents) through a [5+1] annulation-isocyanide cyclization cascade under basic conditions has been developed. This strategy allows the synthesis of polysubstituted dihydroindolones and tetrahydroindolones in high to excellent yields under extremely mild conditions in a single step.
一种新的策略，从活性亚甲基异氰化物和 1,5-双电负性 5-氧代庚-2,6-二烯酸酯（及其等价物）出发，通过在碱性条件下的[5+1]环化-异氰化物环化级联反应，快速构建功能化的还原吲哚，已经被开发出来。该策略允许在极其温和的条件下，在一步中以高产率至优异产率合成多取代的二氢吲哚酮和四氢吲哚酮。
