通过基于异氰化物的多组分串联反应高效选择性合成多取代吡咯。
Highly efficient chemoselective synthesis of polysubstituted pyrroles via isocyanide-based multicomponent domino reaction.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
出版信息
Org Lett. 2013 Aug 16;15(16):4246-9. doi: 10.1021/ol401976w. Epub 2013 Aug 7.
PMID:23924314
Abstract
A multicomponent domino reaction for the chemoselective, catalyst-free synthesis of polysubstituted pyrroles from readily available isocyanides, primary or secondary amines, and gem-diactivated olefins has been developed. Structurally diverse pyrroles were obtained in moderate to good yields under mild conditions.
摘要
一种多组分级联反应已经被开发出来，可以从易得的异氰化物、伯胺或仲胺和偕二官能团烯烃出发，实现对多取代吡咯的化学选择性、无催化剂合成。在温和条件下，以中等至良好的收率得到了结构多样的吡咯。
Zotero 插件