Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Org Lett. 2013 Aug 16;15(16):4246-9. doi: 10.1021/ol401976w. Epub 2013 Aug 7.
A multicomponent domino reaction for the chemoselective, catalyst-free synthesis of polysubstituted pyrroles from readily available isocyanides, primary or secondary amines, and gem-diactivated olefins has been developed. Structurally diverse pyrroles were obtained in moderate to good yields under mild conditions.
一种多组分级联反应已经被开发出来，可以从易得的异氰化物、伯胺或仲胺和偕二官能团烯烃出发，实现对多取代吡咯的化学选择性、无催化剂合成。在温和条件下，以中等至良好的收率得到了结构多样的吡咯。
