Instituto Clínico-Quirúrgico de Oftalmología, Bilbao, Vizcaya, Spain.
Cornea. 2011 Dec;30(12):1312-7. doi: 10.1097/ICO.0b013e31820d86d6.
To evaluate the efficacy of plasma rich in growth factors (PRGF) for the treatment of moderate/severe dry eye.
PRGF treatment was administered to 16 patients who had moderate/severe dry eye diagnosed and who had not responded previously to other standard treatments. We quantified several growth factors present in the PRGF of each patient and obtained quantitative registers of the symptoms (modified score dry eye questionnaire), both before and after PRGF treatment. We also performed impression cytology to determine the degree of squamous metaplasia before and after PRGF treatment.
PRGF treatment was associated with a statistically significant improvement in score dry eye questionnaire values (P < 0.001). Results from impression cytology corroborated this improvement, but the reduction in the degree of squamous metaplasia was not statistically significant. In 75% of patients treated with PRGF, no further treatments were required, whereas in the remaining 25% other ocular treatments could be reduced.
PRGF led to symptom improvement in patients with moderate/severe dry eye. Surprisingly, the symptoms recorded in the dry eye questionnaire do not always agree with the degree of squamous metaplasia measured by impression cytology.
评估富血小板血浆（PRGF）治疗中重度干眼的疗效。
对 16 名中重度干眼患者进行 PRGF 治疗，这些患者经诊断患有中重度干眼，且先前对其他标准治疗无反应。我们对每位患者的 PRGF 中存在的几种生长因子进行了量化，并在 PRGF 治疗前后获得了症状的定量记录（改良干眼问卷评分）。我们还进行了印迹细胞学检查，以确定 PRGF 治疗前后鳞状上皮化生的程度。
PRGF 治疗与评分干眼问卷值的统计学显著改善相关（P < 0.001）。印迹细胞学的结果证实了这一改善，但鳞状上皮化生程度的降低没有统计学意义。在接受 PRGF 治疗的 75%的患者中，不再需要其他治疗，而在其余 25%的患者中，可以减少其他眼部治疗。
PRGF 导致中重度干眼患者症状改善。令人惊讶的是，干眼问卷中记录的症状并不总是与印迹细胞学测量的鳞状上皮化生程度一致。
