Yoon Kyung-Chul, Im Seong-Kyu, Park Yeoung-Geol, Jung Young-Do, Yang Seong-Yeul, Choi Jin
Department of Ophthalmology, Chonnam National University Medical School, Dong Gu, Gwangju, South Korea.
Cornea. 2006 Apr;25(3):268-72. doi: 10.1097/01.ico.0000183484.85636.b6.
To investigate the efficacy of umbilical cord serum eyedrops for the treatment of severe dry eye syndrome.
Fifty-five eyes of 31 patients with severe dry eye syndrome were treated with umbilical cord serum eyedrops. Symptom scoring, tear film break-up time (BUT), Schirmer test, corneal sensitivity test, and corneal fluorescein staining were performed before and 1 and 2 months after treatment, and conjunctival impression cytology was performed before and 2 months after treatment. The concentrations of epidermal growth factor (EGF), vitamin A, and transforming growth factor-beta (TGF-beta) in umbilical cord serum and normal peripheral blood serum were measured.
Two months after treatment, significant improvement was observed in symptom score (from 3.07 +/- 0.54 to 0.96 +/- 0. 58), BUT (from 3.96 +/- 1.56 to 5.45 +/- 2.54 seconds), and keratoepitheliopathy score (from 4.87 +/- 3.22 to 1.71 +/- 1.84) (P < 0.01). There was no statistically significant change in Schirmer and corneal sensitivity tests. In impression cytology, the grade of squamous metaplasia (from 2.35 +/- 0.72 to 1.44 +/- 0.69) and goblet cell density (from 80.91 +/- 31.53 to 154.68 +/- 43.06 cell/mm) improved significantly (P < 0.01). The mean concentrations of EGF, TGF-beta, and vitamin A were 0.48 +/- 0.09, 57.14 +/- 18.98, and 230.85 +/- 13.39 ng/mL in umbilical cord serum and 0.14 +/- 0.03, 31.30 +/- 12.86, and 372.34 +/- 22.32 ng/mL in peripheral blood serum, respectively.
Umbilical cord serum contains essential tear components, and umbilical cord serum eyedrops are effective and safe for the treatment of severe dry eye syndrome.
探讨脐带血清滴眼液治疗重度干眼症的疗效。
对31例重度干眼症患者的55只眼使用脐带血清滴眼液进行治疗。在治疗前以及治疗后1个月和2个月时进行症状评分、泪膜破裂时间（BUT）、泪液分泌试验、角膜敏感度试验和角膜荧光素染色，并在治疗前和治疗后2个月时进行结膜印迹细胞学检查。测定脐带血清和正常外周血血清中表皮生长因子（EGF）、维生素A和转化生长因子-β（TGF-β）的浓度。
治疗2个月后，症状评分（从3.07±0.54降至0.96±0.58）、BUT（从3.96±1.56秒增至5.45±2.54秒）和角膜上皮病变评分（从4.87±3.22降至1.71±1.84）均有显著改善（P<0.01）。泪液分泌试验和角膜敏感度试验无统计学上的显著变化。在印迹细胞学检查中，鳞状化生程度（从2.35±0.72降至1.44±0.69）和杯状细胞密度（从80.91±31.53个/立方毫米增至154.68±43.06个/立方毫米）有显著改善（P<0.01）。脐带血清中EGF、TGF-β和维生素A的平均浓度分别为0.48±0.09、57.14±18.98和230.85±13.3９纳克/毫升，外周血血清中分别为0.14±0.03、31.30±12.86和372.34±22.32纳克/毫升。
脐带血清含有泪液的重要成分，脐带血清滴眼液治疗重度干眼症有效且安全。
