Petros S, Siegemund R
Interdisziplinäre Internistische Intensivmedizin, Universitätsklinikum Leipzig AöR, Liebigstrasse 20, Leipzig, Germany.
Med Klin Intensivmed Notfmed. 2011 Nov;106(3):166-70. doi: 10.1007/s00063-011-0013-x. Epub 2011 Oct 21.
Hemostasis is an important component of host defense and wound healing. During the last few decades, the interaction between hemostasis and inflammation has moved into the center of research. Thrombin, which is considered the central enzyme of the hemostatic system, plays a key role in these investigations. Immune modulatory treatment strategies, such as the supraphysiological doses of antithrombin and activated protein C in sepsis, were based on scientific investigations of thrombin generation and its role in inflammatory reactions. However, the complex function of thrombin has not yet been fully elucidated.
止血是宿主防御和伤口愈合的重要组成部分。在过去几十年中，止血与炎症之间的相互作用已成为研究的核心。凝血酶被认为是止血系统的中心酶，在这些研究中起着关键作用。免疫调节治疗策略，如脓毒症中使用超生理剂量的抗凝血酶和活化蛋白C，是基于对凝血酶生成及其在炎症反应中作用的科学研究。然而，凝血酶的复杂功能尚未完全阐明。
