压力让 TIA 更易发作。
Stress puts TIA on TOP.
机构信息
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
出版信息
Genes Dev. 2011 Oct 15;25(20):2119-24. doi: 10.1101/gad.17838411.
Abstract
Under conditions of limited nutrients, eukaryotic cells reprogram protein expression in a way that slows growth but enhances survival. Recent data implicate stress granules, discrete cytoplasmic foci into which untranslated mRNPs are assembled during stress, in this process. In the October 1, 2011, issue of Genes & Development, Damgaard and Lykke-Andersen (p. 2057-2068) provide mechanistic insights into the regulation of a specific subset of mRNAs bearing 5'-terminal oligopyrimidine tracts (5'TOPs) by the structurally related stress granule proteins TIA-1 and TIAR.
摘要
在营养有限的条件下，真核细胞会重新编程蛋白质表达，以减缓生长速度但增强生存能力。最近的数据表明，应激颗粒，即细胞质中的离散焦点，在这个过程中，将未翻译的 mRNPs 组装到其中，参与了这个过程。在 2011 年 10 月 1 日的《基因与发育》杂志上，Damgaard 和 Lykke-Andersen（第 2057-2068 页）提供了关于结构相关的应激颗粒蛋白 TIA-1 和 TIAR 调节特定亚类带有 5'-末端寡嘧啶序列（5'TOPs）的 mRNAs 的机制见解。
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本文引用的文献
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