H7N1 流感病毒 NA 茎长度的变化对鸡和鸭中病毒的排泄有相反的影响。
Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks.
机构信息
Equipe BioVA, INRA UR1282, Infectiologie Animale et Santé Publique, IASP, 37380 Nouzilly, France.
出版信息
J Virol. 2012 Jan;86(1):584-8. doi: 10.1128/JVI.05474-11. Epub 2011 Oct 19.
Abstract
A deletion of ∼20 amino acids in the stalk of neuraminidase is frequently observed upon transmission of influenza A viruses from waterfowl to domestic poultry. A pair of recombinant H7N1 viruses bearing either a short- or long-stalk neuraminidase was genetically engineered. Inoculation of the long-stalk-neuraminidase virus resulted in a higher cloacal excretion in ducks and led conversely to lower-level oropharyngeal excretion in chickens, associated with a higher-level local immune response and better survival. Therefore, a short-stalk neuraminidase is a determinant of viral adaptation and virulence in chickens but is detrimental to virus replication and shedding in ducks.
摘要
在流感病毒从水禽传播到家禽的过程中，神经氨酸酶茎干中约 20 个氨基酸的缺失经常发生。一对携带短茎或长茎神经氨酸酶的重组 H7N1 病毒被遗传工程改造。接种长茎神经氨酸酶病毒会导致鸭子的泄殖腔排泄物更高，而鸡的口腔排泄物水平则相反较低，这与更高水平的局部免疫反应和更好的存活率有关。因此，短茎神经氨酸酶是病毒在鸡中适应和毒力的决定因素，但对病毒在鸭中的复制和脱落不利。
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