Parmentier S, Kaplan C, Catimel B, McGregor J L
INSERM U.331, Faculté de Médecine Alexis Carrel, Lyon, France.
Immunol Today. 1990 Jul;11(7):225-7. doi: 10.1016/0167-5699(90)90089-r.
Adhesion molecules play a crucial part in cell-matrix and in cell-cell interactions. These interactions, which are essential to the body's defense processes, involve adhesion molecules belonging to different families: integrins, immunoglobulins and selectins. Integrins are expressed by a large number of tissues, whereas other adhesion molecule families are restricted to a small number of cell types. A recent symposium dealt with the recruitment of circulating platelets at specific sites, their adhesion to extracellular matrix components and their activation by agonists leading to aggregation or attachment to other cells. These events, supporting hemostasis and thrombosis, involve integrins, selectins and other adhesion molecules. This report focuses on newly reported integrins (GPIa, GPIc, GPIIa), selectins (GMP-140) and GPIIIb, previously known as 'minor' surface oriented platelet glycoproteins. Major membrane glycoproteins such as GPIIb-IIIa (an integrin) and GPIb, which also play a vital role in platelet functions, have been extensively reviewed elsewhere.
黏附分子在细胞与基质以及细胞与细胞的相互作用中起着关键作用。这些对机体防御过程至关重要的相互作用涉及不同家族的黏附分子：整合素、免疫球蛋白和选择素。整合素在大量组织中表达，而其他黏附分子家族则局限于少数细胞类型。最近的一次研讨会讨论了循环血小板在特定部位的募集、它们与细胞外基质成分的黏附以及它们被激动剂激活从而导致聚集或与其他细胞附着的过程。这些支持止血和血栓形成的事件涉及整合素、选择素和其他黏附分子。本报告重点关注新报道的整合素（GPIa、GPIc、GPIIa）、选择素（GMP-140）和GPIIIb，GPIIIb以前被称为“次要”的面向表面的血小板糖蛋白。主要的膜糖蛋白如GPIIb-IIIa（一种整合素）和GPIb，它们在血小板功能中也起着至关重要的作用，在其他地方已有广泛综述。
