Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.
Int J Toxicol. 2011 Oct;30(5):562-7. doi: 10.1177/1091581811415294.
The ability of 2 combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) to reactivate VX-inhibited acetylcholinesterase and reduce acute toxicity of VX was compared with the reactivating and therapeutic efficacy of antidotal treatment involving a single oxime (HI-6, trimedoxime, K203) in rats and mice. Our results showed that the reactivating efficacy of both combinations of oximes studied in rats is significantly higher than the reactivating efficacy of all individual oximes in diaphragm and roughly corresponds to the most effective individual oxime in blood and brain. Both combinations of oximes were found to be more effective in the reduction of acute lethal toxicity of VX in mice than the antidotal treatment involving the most efficacious individual oxime although the difference is not significant. Based on the obtained data, we can conclude that the antidotal treatment involving the chosen combinations of oximes brings benefit for the reactivation of VX-inhibited acetylcholinesterase in rats and for the antidotal treatment of VX-induced acute poisoning in mice.
两种肟类化合物（HI-6+trimedoxime 和 HI-6+K203）组合与单一肟类化合物（HI-6、trimedoxime、K203）解毒治疗对VX 抑制乙酰胆碱酯酶的复活作用和降低 VX 急性毒性的能力在大鼠和小鼠中进行了比较。我们的结果表明，研究中两种肟类化合物组合在大鼠中的复活效果明显高于所有单个肟类化合物在横膈膜中的复活效果，大致与血液和大脑中最有效的单个肟类化合物相当。两种肟类化合物组合在降低 VX 在小鼠中的急性致死毒性方面均比最有效的单个肟类化合物解毒治疗更有效，尽管差异不显著。基于获得的数据，我们可以得出结论，选择的肟类化合物组合解毒治疗对 VX 抑制乙酰胆碱酯酶在大鼠中的复活和 VX 诱导的急性中毒的解毒治疗有一定益处。
