Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Physiology (Bethesda). 2011 Oct;26(5):334-47. doi: 10.1152/physiol.00011.2011.
This manuscript will review our current understanding of neutrophilic polymorphonuclear leukocyte (neutrophil) interactions with the endothelium during immune and inflammatory responses, focusing on the molecular mechanisms regulating neutrophil adhesion to and migration through the endothelium in response to infection or tissue injury. This is a complex and dynamic area of research and one that has been the topic of several recent comprehensive reviews to which the interested reader is referred (64, 118, 131). By design, this review will begin with a brief review of some basic aspects of neutrophil biology and endothelial adhesion to provide a foundation. The remainder of the review will focus on selected areas of this complex field, specifically the role of the endothelial glycocalyx in regulating neutrophil adhesion and the mechanisms and consequences of migration of neutrophils between (paracellular) and through (transcellular) endothelial cells during egress from the vasculature.
这篇手稿将回顾我们目前对中性粒细胞与内皮细胞在免疫和炎症反应中的相互作用的理解，重点介绍调节中性粒细胞在感染或组织损伤时黏附和穿过内皮细胞的分子机制。这是一个复杂而动态的研究领域，也是最近几篇综合综述的主题，有兴趣的读者可参考这些综述（64、118、131）。本综述将简要回顾中性粒细胞生物学和内皮细胞黏附的一些基本方面，以此作为基础。综述的其余部分将集中讨论这个复杂领域的选定领域，特别是内皮细胞糖萼在调节中性粒细胞黏附中的作用，以及中性粒细胞在血管外渗过程中通过（细胞间）和穿过（细胞内）内皮细胞迁移的机制和后果。
