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本文引用的文献

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An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C.基于 IL28B 基因型的慢性丙型肝炎治疗临床预测模型。
PLoS One. 2011;6(7):e20904. doi: 10.1371/journal.pone.0020904. Epub 2011 Jul 8.
2
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.HCV 替换和 IL28B 多态性对聚乙二醇干扰素联合利巴韦林治疗的影响。
Gut. 2011 Feb;60(2):261-7. doi: 10.1136/gut.2010.223495. Epub 2010 Nov 10.
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IL28B and the control of hepatitis C virus infection.IL28B 与丙型肝炎病毒感染的控制。
Gastroenterology. 2010 Dec;139(6):1865-76. doi: 10.1053/j.gastro.2010.10.004. Epub 2010 Oct 13.
4
A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.IL28B 附近的一种多态性与急性丙型肝炎病毒和黄疸的自发清除有关。
Gastroenterology. 2010 Nov;139(5):1586-92, 1592.e1. doi: 10.1053/j.gastro.2010.07.005. Epub 2010 Jul 14.
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An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response.IL28B 基因多态性可预测未获得快速病毒学应答的 HCV 基因 2 或 3 型患者的治疗反应。
Gastroenterology. 2010 Sep;139(3):821-7, 827.e1. doi: 10.1053/j.gastro.2010.05.079. Epub 2010 Jun 2.
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Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.白细胞介素 28B 多态性可改善病毒动力学，是基因型 1 丙型肝炎病毒持续病毒学应答的最强预处理预测因子。
Gastroenterology. 2010 Jul;139(1):120-9.e18. doi: 10.1053/j.gastro.2010.04.013. Epub 2010 Apr 24.
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Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.IL28B 基因变异与慢性丙型肝炎及治疗失败相关：一项全基因组关联研究。
Gastroenterology. 2010 Apr;138(4):1338-45, 1345.e1-7. doi: 10.1053/j.gastro.2009.12.056. Epub 2010 Jan 11.
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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.白细胞介素28B的基因变异与丙型肝炎病毒的自发清除
Nature. 2009 Oct 8;461(7265):798-801. doi: 10.1038/nature08463.
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MBL2 and hepatitis C virus infection among injection drug users.注射吸毒者中的甘露聚糖结合凝集素2（MBL2）与丙型肝炎病毒感染
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10
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IL28B rs12979860 基因型与注射吸毒者多民族队列中丙型肝炎病毒的自发清除：超加性关联的证据。

IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.

机构信息

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

出版信息

J Infect Dis. 2011 Dec 15;204(12):1843-7. doi: 10.1093/infdis/jir647. Epub 2011 Oct 19.

DOI:10.1093/infdis/jir647
PMID:22013224
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3209810/
Abstract

Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860, adjusted odds ratios for spontaneous HCV clearance were as follows: IL28B-CC, 3.88 (P < .001); IL28B-CT, 1.48 (P = .08). On the basis of Akaike information criteria values and χ(2) tests, a supra-additive (quadratic) model fit these data best. Models based on rs8099917 provided poorer fit. Evidence that a supra-additive rs12979860-based model best fits the association of IL28B-genotype with HCV clearance may improve clinical prediction models and foster a better understanding of functional mechanisms underlying this association.

摘要

在 1369 名城市健康研究参与者中，我们评估了 IL28B 基因型（rs12979860 和 rs8099917）与丙型肝炎病毒（HCV）清除之间关联的遗传模型。对于 rs12979860，自发性 HCV 清除的调整后优势比如下：IL28B-CC，3.88（P<.001）；IL28B-CT，1.48（P=.08）。基于赤池信息量准则值和 χ(2)检验，超加性（二次）模型最适合这些数据。基于 rs8099917 的模型拟合效果较差。IL28B 基因型与 HCV 清除之间关联的超加性 rs12979860 模型最佳拟合的证据可能会改善临床预测模型，并促进对这种关联的功能机制的更好理解。