IL28B rs12979860 基因型与注射吸毒者多民族队列中丙型肝炎病毒的自发清除：超加性关联的证据。
IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.
机构信息
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
出版信息
J Infect Dis. 2011 Dec 15;204(12):1843-7. doi: 10.1093/infdis/jir647. Epub 2011 Oct 19.
Abstract
Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860, adjusted odds ratios for spontaneous HCV clearance were as follows: IL28B-CC, 3.88 (P < .001); IL28B-CT, 1.48 (P = .08). On the basis of Akaike information criteria values and χ(2) tests, a supra-additive (quadratic) model fit these data best. Models based on rs8099917 provided poorer fit. Evidence that a supra-additive rs12979860-based model best fits the association of IL28B-genotype with HCV clearance may improve clinical prediction models and foster a better understanding of functional mechanisms underlying this association.
摘要
在 1369 名城市健康研究参与者中，我们评估了 IL28B 基因型（rs12979860 和 rs8099917）与丙型肝炎病毒（HCV）清除之间关联的遗传模型。对于 rs12979860，自发性 HCV 清除的调整后优势比如下：IL28B-CC，3.88（P<.001）；IL28B-CT，1.48（P=.08）。基于赤池信息量准则值和 χ(2)检验，超加性（二次）模型最适合这些数据。基于 rs8099917 的模型拟合效果较差。IL28B 基因型与 HCV 清除之间关联的超加性 rs12979860 模型最佳拟合的证据可能会改善临床预测模型，并促进对这种关联的功能机制的更好理解。
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1
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PLoS One. 2011;6(7):e20904. doi: 10.1371/journal.pone.0020904. Epub 2011 Jul 8.
2
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Gut. 2011 Feb;60(2):261-7. doi: 10.1136/gut.2010.223495. Epub 2010 Nov 10.
3
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4
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6
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Gastroenterology. 2010 Jul;139(1):120-9.e18. doi: 10.1053/j.gastro.2010.04.013. Epub 2010 Apr 24.
7
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Gastroenterology. 2010 Apr;138(4):1338-45, 1345.e1-7. doi: 10.1053/j.gastro.2009.12.056. Epub 2010 Jan 11.
8
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.白细胞介素28B的基因变异与丙型肝炎病毒的自发清除
Nature. 2009 Oct 8;461(7265):798-801. doi: 10.1038/nature08463.
9
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BMC Infect Dis. 2008 May 1;8:57. doi: 10.1186/1471-2334-8-57.
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