Juneja Deven, Javeri Yash, Singh Omender, Nasa Prashant, Pandey Rameshwar, Uniyal Bhupesh
Department of Critical Care Medicine, Max Super Speciality Hospital, New Delhi, India.
Indian J Crit Care Med. 2011 Jul;15(3):168-72. doi: 10.4103/0972-5229.84902.
Intermittent subglottic drainage (ISD) of secretions is recommended for prevention of ventilator-associated pneumonia (VAP) as it reduces microaspiration from the area around the cuff. Poor suction techniques can contribute to VAP, hence closed suction system (CSS) may have theoretical benefit in VAP prevention. Combination of these two techniques may provide added advantage.
To study the influence of ISD with/without CSS on the incidence of VAP.
Data from 311 patients requiring mechanical ventilation (MV) for more than 72 hours were collected retrospectively. They were divided into four groups as follows: group A, no intervention; group B, only CSS; group C, only ISD; and group D, ISD with CSS. These groups were compared with respect to incidence of VAP, duration of MV, length of ICU and hospital stay and ICU mortality.
Patients in the four groups were comparable with respect to age, sex ratio and admission Acute Physiology and Chronic Health Evaluation (APACHE) II scores. Incidence of VAP per 1000 ventilator days in groups A, B, C, and D were 25, 23.9, 15.7 and 14.3, respectively (P=0.04). There was no significant difference in the duration of MV (P=0.33), length of ICU (P=0.55) and hospital stay (P=0.36) and ICU mortality (P=0.9) among the four groups.
ISD of secretions reduces the incidence of VAP. CSS alone or in combination with ISD has no significant effect on VAP incidence. Hence, ISD may be recommended for VAP prevention, but indications other than VAP prevention should determine the type of the suction system.
推荐对分泌物进行间歇性声门下引流(ISD)以预防呼吸机相关性肺炎(VAP),因为它可减少套囊周围区域的微量误吸。较差的吸痰技术可能导致VAP,因此封闭式吸痰系统(CSS)在预防VAP方面可能具有理论上的益处。这两种技术的联合应用可能会带来额外的优势。
研究有无CSS的ISD对VAP发生率的影响。
回顾性收集311例需要机械通气(MV)超过72小时的患者的数据。他们被分为四组如下:A组,不进行干预;B组,仅使用CSS;C组,仅使用ISD;D组,ISD联合CSS。比较这些组在VAP发生率、MV持续时间、ICU和住院时间以及ICU死亡率方面的情况。
四组患者在年龄、性别比和入院急性生理与慢性健康状况评估(APACHE)II评分方面具有可比性。A、B、C、D组每1000个呼吸机日的VAP发生率分别为25、23.9、15.7和14.3(P = 0.04)。四组之间在MV持续时间(P = 0.33)、ICU住院时间(P = 0.55)、住院时间(P = 0.36)和ICU死亡率(P = 0.9)方面无显著差异。
分泌物的ISD可降低VAP的发生率。单独使用CSS或与ISD联合使用对VAP发生率无显著影响。因此,对于VAP预防可推荐使用ISD,但除VAP预防之外的其他指征应决定吸痰系统的类型。