Tombal Bertrand, Lecouvet Frederic
Division of Urology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
Adv Urol. 2012;2012:893193. doi: 10.1155/2012/893193. Epub 2011 Oct 16.
Prostate cancer cells have an exquisite tropism for bone, which clinically translates into the highest rate of bone metastases amongst male cancers. Although in the latest years there has been an active development of new "bone targeted" therapies, modern diagnostic techniques for bone metastases still relies mostly on (99m)Tc bone scanning (BS) and plain X-ray. BS dramatically lacks specificity and sensitivity. Recent publications using modern imaging technologies have clearly pinpointed that BS grossly underestimates the true prevalence of bone metastasis. In addition BS does not allow tumour measurement and is, therefore, not appropriate to monitor response to therapy. This might be extremely important in patients harbouring high-risk localized disease that are eventually candidate for local therapy. Here we reviewed what are the emerging imaging strategies that are likely to supplant BS and to what extent they can be used in the clinic already.
前列腺癌细胞对骨具有高度的嗜性，在临床上这表现为男性癌症中骨转移率最高。尽管近年来新的“骨靶向”疗法得到了积极发展，但目前用于骨转移的现代诊断技术仍主要依赖于（99m）锝骨扫描（BS）和平片X线检查。骨扫描明显缺乏特异性和敏感性。近期使用现代成像技术的研究明确指出，骨扫描严重低估了骨转移的实际发生率。此外，骨扫描无法进行肿瘤测量，因此不适用于监测治疗反应。这对于患有高危局限性疾病且最终可能接受局部治疗的患者可能极为重要。在此，我们回顾了哪些新兴成像策略可能会取代骨扫描，以及它们目前在临床中的应用程度。
