Jahanshahi Gholamreza, Haghighat Abbas, Azmoodeh Faezeh
Associate Professor, Department of Oral & Maxillofacial Pathology and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2011 Summer;8(3):150-3.
The neurilemmoma is a benign neoplasm of Schwann cell origin. One of the histopathologic subtypes of this tumor is ancient schwannoma which is characterized by degenerative alterations including cystic change, calcification, hemorrhage, and hyalinization.Intraosseous schwannomas especially ancient ones are rare tumors. Here we present a case of intraosseous ancient schwannoma in the lower jaw of an 11-year-old girl which caused a non-tender expansion. Radiographic examination showed a well-circumscribed, unilocular radiolucent lesion with thin sclerotic borders in the mandibular body and the ramus. Histopathologic examination of the incisional biopsy showed areas of typical Antoni A with verocay bodies and Antoni B that was strongly suggestive of a schwannoma. Complete excision of the lesion was done under general anesthesia. The histopathologic examination confirmed the primary diagnosis and also degenerative changes such as hyalinization and calcification. Based on these findings, the diagnosis of ancient schwannoma was made. No recurrence was observed in the follow-up examination after 3 months.
神经鞘瘤是一种起源于施万细胞的良性肿瘤。该肿瘤的组织病理学亚型之一是陈旧性神经鞘瘤,其特征为退行性改变,包括囊性变、钙化、出血和玻璃样变。骨内神经鞘瘤,尤其是陈旧性神经鞘瘤,是罕见的肿瘤。在此,我们报告一例发生于一名11岁女孩下颌骨的骨内陈旧性神经鞘瘤病例,该肿瘤导致无痛性膨隆。影像学检查显示下颌体和下颌支有一个边界清晰、单房性的透射性病变,边界有薄的硬化边。切开活检的组织病理学检查显示有典型的伴有Verocay小体的Antoni A区和Antoni B区,强烈提示为神经鞘瘤。在全身麻醉下对病变进行了完整切除。组织病理学检查证实了初步诊断,同时也发现了玻璃样变和钙化等退行性改变。基于这些发现,诊断为陈旧性神经鞘瘤。3个月后的随访检查未观察到复发。