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腹腔转移攻击的第一道防线：突破间皮细胞层。

The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.

机构信息

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology - Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.

出版信息

Cancer Discov. 2011 Jul;1(2):100-2. doi: 10.1158/2159-8290.CD-11-0117.

DOI:10.1158/2159-8290.CD-11-0117
PMID:22013555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3193939/
Abstract

Iwanicki and colleagues reveal that ovarian cancer spheroids clear mesothelial cells which cover the surface of the abdominal cavity using myosin-generated force.

摘要

伊万尼茨基等人揭示，卵巢癌细胞球体利用肌球蛋白产生的力清除覆盖腹腔表面的间皮细胞。

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Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.卵巢癌细胞球利用肌球蛋白产生的力清除间皮。
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本文引用的文献

1
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.卵巢癌细胞球利用肌球蛋白产生的力清除间皮。
Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010.
2
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.整合素 α5β1 通过增强收缩力促进癌细胞侵袭。
J Cell Sci. 2011 Feb 1;124(Pt 3):369-83. doi: 10.1242/jcs.071985. Epub 2011 Jan 11.
3
Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis.纤维连接蛋白和 α(5)β(1)-整合素对 c-Met 的配体非依赖性激活调节卵巢癌的侵袭和转移。
Oncogene. 2011 Mar 31;30(13):1566-76. doi: 10.1038/onc.2010.532. Epub 2010 Nov 29.
4
Ovarian cancer development and metastasis.卵巢癌的发生和转移。
Am J Pathol. 2010 Sep;177(3):1053-64. doi: 10.2353/ajpath.2010.100105. Epub 2010 Jul 22.
5
Cancer statistics, 2010.癌症统计数据，2010 年。
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
6
Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin.衰老的腹膜间皮细胞促进卵巢癌细胞黏附：氧化应激诱导的纤连蛋白的作用。
Am J Pathol. 2009 Apr;174(4):1230-40. doi: 10.2353/ajpath.2009.080613. Epub 2009 Feb 26.
7
Endostatin binding to ovarian cancer cells inhibits peritoneal attachment and dissemination.内皮抑素与卵巢癌细胞结合可抑制腹膜附着和扩散。
Cancer Res. 2007 Nov 15;67(22):10813-22. doi: 10.1158/0008-5472.CAN-07-0172.
8
Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.使用一种新型三维培养模型来阐明间皮细胞、成纤维细胞和细胞外基质对卵巢癌细胞黏附及侵袭大网膜的作用。
Int J Cancer. 2007 Oct 1;121(7):1463-72. doi: 10.1002/ijc.22874.
9
Tumour-induced apoptosis in human mesothelial cells: a mechanism of peritoneal invasion by Fas Ligand/Fas interaction.肿瘤诱导人腹膜间皮细胞凋亡：Fas配体/Fas相互作用介导的腹膜侵袭机制
Br J Cancer. 2004 Apr 5;90(7):1437-42. doi: 10.1038/sj.bjc.6601635.
10
Adhesion-dependent cell mechanosensitivity.黏附依赖性细胞机械敏感性。
Annu Rev Cell Dev Biol. 2003;19:677-95. doi: 10.1146/annurev.cellbio.19.111301.153011.