血管化肿瘤芯片的最新进展
Recent advances in vascularized tumor-on-a-chip.
作者信息
Huang Christina Bao Xian, Tu Ting-Yuan
机构信息
Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan.
出版信息
Front Oncol. 2023 Mar 30;13:1150332. doi: 10.3389/fonc.2023.1150332. eCollection 2023.
The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of replicating conditions with exceptional spatiotemporal resolution, making it a significant asset in cancer research. This review delves into the latest developments in 3D microfluidic vascularized tumor models and their applications , focusing on heterotypic cellular interactions, the mechanisms of metastasis, and therapeutic screening. Additionally, the review examines the benefits and drawbacks of these models, as well as the future prospects for their advancement.
脉管系统在癌症进展和转移中起着关键作用，是创建癌症模型的一个关键方面。近年来，芯片器官技术的出现已被证明是一种强大的工具，能够以卓越的时空分辨率复制条件，使其成为癌症研究中的一项重要资产。本综述深入探讨了三维微流控血管化肿瘤模型的最新进展及其应用，重点关注异型细胞相互作用、转移机制和治疗筛选。此外，该综述还考察了这些模型的优缺点以及它们进一步发展的未来前景。
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