Kang Xin-zhong, Wu Qi-fu, Jie Hong-yu
Nanfang Hospital, Southern Medical University, Guangzhou 510515.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Sep;31(9):1205-8.
To observe the clinical efficacy of Wangbi Tablet (WT) on the treatment of knee osteoarthritis (KOA), and to study its treatment program by integrative medicine.
The randomized, parallel control, and multi-center clinical observation method was used. 160 KOA patients of Gan-Shen deficiency complicated with stasis-blood blockade syndrome were assigned to three groups. Group A (72 cases) was treated by WT, Group B (42 cases) was treated by Votalin Tablet, and Group C (46 cases) was treated by WT + Votalin Tablet. All patients were treated for two months. Before and after treatment the clinical symptoms, the knee function activity, adverse reactions were observed and recorded. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of each patient were respectively detected, statistically analyzed and compared.
After eight weeks of treatment significant difference was shown in the time of morning stiffness in joints, joint tendemess, swelling, pain, joint functional activities, ESR, and CRP between Group A and Group B (P<0.01). Besides, better effects were obtained in Group C (P<0.01). Improvement of ESR and CRP: They were obviously improved in the three groups after treatment (P<0.01). As for the markedly effective rate, better effects were obtained in Group C (P<0.05).
In the treatment of KOA, WT showed favorable effects with no obvious adverse reaction. The combination of WT and Voltaren Tablet was significantly superior to use of WT or Votalin Tablet alone. It could reduce the dosage of Voltaren Tablet and avoid adverse reactions of the gastrointestinal tract.
观察尪痹片治疗膝骨关节炎（KOA）的临床疗效，并探讨其中西医结合治疗方案。
采用随机、平行对照、多中心临床观察方法。将160例肝肾亏虚兼瘀血阻滞证的KOA患者分为三组。A组（72例）采用尪痹片治疗，B组（42例）采用扶他林片治疗，C组（46例）采用尪痹片联合扶他林片治疗。所有患者均治疗2个月。观察并记录治疗前后的临床症状、膝关节功能活动及不良反应。分别检测每位患者的红细胞沉降率（ESR）和C反应蛋白（CRP），进行统计学分析和比较。
治疗8周后，A组与B组在关节晨僵时间、关节压痛、肿胀、疼痛、关节功能活动、ESR及CRP方面差异有统计学意义（P<0.01）。此外，C组疗效更佳（P<0.01）。ESR和CRP的改善情况：三组治疗后均明显改善（P<0.01）。在显效率方面，C组效果更佳（P<0.05）。
在KOA治疗中，尪痹片疗效良好，无明显不良反应。尪痹片与扶他林片联合应用明显优于单独使用尪痹片或扶他林片，可减少扶他林片用量，避免胃肠道不良反应。
