Department of Medicine, Section of Dermatology and Venereology, Section of Rheumatology III Division of Geriatrics, University of Verona, Verona, Italy.
Br J Dermatol. 2012 Mar;166(3):505-10. doi: 10.1111/j.1365-2133.2011.10699.x. Epub 2012 Feb 6.
Vitamin D could have important immunomodulatory effects in psoriasis.
To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.
A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected.
The prevalence of vitamin D deficiency [25(OH)D levels <20ngmL(-1) ] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls (P<0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls (P<0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established.
Vitamin D deficiency may be common in patients with psoriasis, especially in winter.
维生素 D 可能对银屑病具有重要的免疫调节作用。
测量银屑病患者的 25-羟维生素 D [25(OH)D]、甲状旁腺激素 (PTH) 和血清钙水平，并探讨其与某些相关临床特征的关系。
进行了一项为期 1 年的横断面研究，纳入了 145 例慢性斑块状银屑病患者、112 例类风湿关节炎 (RA) 患者和 141 例健康对照者。在一个集中的实验室测量了 25(OH)D、PTH 和血清钙水平。收集了人口统计学、合并症、疾病严重程度和暴露于阳光的时间(通过问卷获得)等信息。
银屑病患者维生素 D 缺乏症(25(OH)D 水平<20ng/mL)的患病率为 57.8%，而 RA 患者和健康对照者的患病率分别为 37.5%和 29.7%(P<0.001)。在冬季，银屑病患者维生素 D 缺乏症的患病率上升至 80.9%，RA 患者为 41.3%，健康对照者为 30.3%(P<0.001)。银屑病患者和银屑病关节炎患者的 25(OH)D 血清水平或维生素 D 缺乏症的患病率并无差异。在 logistic 回归分析中，维生素 D 缺乏与银屑病独立相关，与年龄、性别、体重指数、钙、PTH 水平和采血季节无关。该研究的局限性在于，研究设计不允许建立维生素 D 缺乏与银屑病之间的因果或时间关系。
维生素 D 缺乏可能在银屑病患者中很常见，尤其是在冬季。
