Zhang Xiaoya, Xie Guiqiu, Rao Lang, Tian Chaoguang
National Technology Innovation Center of Synthetic Biology, Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
School of Pharmacy, Jilin University, Changchun 130012, China.
Genes Dis. 2024 Jun 22;12(4):101355. doi: 10.1016/j.gendis.2024.101355. eCollection 2025 Jul.
Protein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases. This process is an important protein post-translational modification that affects molecular structure and function of various proteins, including histones. In recent years, protein citrullination has attracted widespread attention for its influence on gene transcription. Studies on the impact of protein citrullination modification on chromatin structure remodeling and the establishment of gene regulatory networks have made rapid progress. In this review, we briefly summarize the physiological functions of protein citrullination modification. Specifically, we comprehensively outline the latest progress in the study of the role of protein citrullination modification in gene transcription regulation, focusing on the interaction of protein citrullination with other post-translational modifications.
蛋白质瓜氨酸化涉及肽链中的精氨酸或甲基精氨酸残基通过肽基精氨酸脱亚氨酶脱氨形成瓜氨酸。这一过程是一种重要的蛋白质翻译后修饰，会影响包括组蛋白在内的各种蛋白质的分子结构和功能。近年来，蛋白质瓜氨酸化因其对基因转录的影响而受到广泛关注。关于蛋白质瓜氨酸化修饰对染色质结构重塑和基因调控网络建立的影响的研究取得了快速进展。在这篇综述中，我们简要总结了蛋白质瓜氨酸化修饰的生理功能。具体而言，我们全面概述了蛋白质瓜氨酸化修饰在基因转录调控中作用研究的最新进展，重点关注蛋白质瓜氨酸化与其他翻译后修饰的相互作用。
