银屑病患者的血清25-羟基维生素D水平及其与对照受试者的比较。
Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects.
作者信息
Maleki Masoud, Nahidi Yalda, Azizahari Sahar, Meibodi Naser Tayyebi, Hadianfar Ali
机构信息
Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
出版信息
J Cutan Med Surg. 2016 May;20(3):207-10. doi: 10.1177/1203475415622207. Epub 2015 Dec 9.
BACKGROUND
Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis.
OBJECTIVES
The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls.
METHODS
This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay.
RESULTS
The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant (P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls (P = .21).
CONCLUSIONS
Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.
背景
维生素D已被证明具有免疫调节作用，先前的研究提出维生素D缺乏在包括银屑病在内的多种自身免疫性疾病中起作用。
目的
本研究旨在调查银屑病患者的血清维生素D水平，并将其与对照组的水平进行比较。
方法
本研究对50例银屑病患者进行。采用酶联免疫吸附测定法测定血清维生素D。
结果
银屑病患者和对照组的血清维生素D平均水平分别为14.92±6.31和12.52±4.54 ng/mL。差异无统计学意义（P = 0.06）。银屑病患者维生素D缺乏（<20 ng/mL）的患病率为84.0%，对照组为93.0%（P = 0.21）。
结论
大多数银屑病患者存在维生素D缺乏，这可能促使了他们银屑病的发展。然而，考虑到伊朗维生素D缺乏的高患病率，银屑病患者与对照组之间未发现差异。
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